Pavel I. Zimin, Ph.D.

Affiliations: 
2010 Pharmacology and Toxicology University of California, Davis, Davis, CA 
Area:
Pharmacology, Immunology, General Biophysics
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"Pavel Zimin"
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Heike Wulff grad student 2010 UC Davis
 (Mechanism of action and in vivo effects of the novel immunosuppressant PAP-1.)
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Publications

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Hao B, Chen ZW, Zhou XJ, et al. (2011) Identification of phase-I metabolites and chronic toxicity study of the Kv1.3 blocker PAP-1 (5-(4-phenoxybutoxy)psoralen) in the rat. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 41: 198-211
Maezawa I, Zimin PI, Wulff H, et al. (2011) Amyloid-beta protein oligomer at low nanomolar concentrations activates microglia and induces microglial neurotoxicity. The Journal of Biological Chemistry. 286: 3693-706
Zimin PI, Garic B, Bodendiek SB, et al. (2010) Potassium channel block by a tripartite complex of two cationophilic ligands and a potassium ion. Molecular Pharmacology. 78: 588-99
Zimin PI, Garic B, Wulff H, et al. (2010) Potassium Channel Block by a Tripartite Complex of Neutral Ligands with a Potassium Ion Biophysical Journal. 98: 115a
Sankaranarayanan A, Raman G, Busch C, et al. (2009) Naphtho[1,2-d]thiazol-2-ylamine (SKA-31), a new activator of KCa2 and KCa3.1 potassium channels, potentiates the endothelium-derived hyperpolarizing factor response and lowers blood pressure. Molecular Pharmacology. 75: 281-95
Zimin PI, Garic B, Wulff H, et al. (2009) Mapping the Binding Site of the Alkoxypsoralen PAP-1 in the Voltage-Gated K+ Channel Kv1.3 Biophysical Journal. 96: 176a
Wulff H, Sankaranarayanan A, Raman G, et al. (2009) SKA-31, A New Activator of KCa2 And KCa3.1 Potassium Channels, Potentiates the EDHF Response and Lowers Blood Pressure Biophysical Journal. 96: 475a-476a
Beeton C, Wulff H, Standifer NE, et al. (2006) Kv1.3 channels are a therapeutic target for T cell-mediated autoimmune diseases. Proceedings of the National Academy of Sciences of the United States of America. 103: 17414-9
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