Ernesto Freire
Affiliations: | Johns Hopkins University, Baltimore, MD |
Area:
General Biophysics, Biochemistry, PharmacologyWebsite:
http://bio.jhu.edu/directory/ernesto-freire/Google:
"Ernesto Freire"Mean distance: (not calculated yet)
Parents
Sign in to add mentor| Rodney Lincoln Biltonen | grad student | 1977 | UVA | |
| (Statistical thermodynamics of conformational transitions in macromolecules.) | ||||
Children
Sign in to add trainee| Beth A. Goins | grad student | 1988 | University of Tennessee |
| Vincent J. Hilser | grad student | 1995 | Johns Hopkins (Physics Tree) |
| Olga V. Boudker | grad student | 2000 | Johns Hopkins |
| Jose A. D'Aquino Ruiz | grad student | 2000 | Johns Hopkins |
| Azin G. Nezami | grad student | 2004 | Johns Hopkins |
| Stephanie A. Leavitt | grad student | 2006 | Johns Hopkins |
| Usman M. Bacha | grad student | 2008 | Johns Hopkins |
| Adam J. Ruben | grad student | 2008 | Johns Hopkins |
| Jennifer A. Barrila | grad student | 2009 | Johns Hopkins |
| Erik A. Billings | grad student | 2009 | Johns Hopkins |
| Evan T. Brower | grad student | 2009 | Johns Hopkins |
| Vinod Bhakuni | post-doc | Johns Hopkins | |
| Craig R Johnson | post-doc | 1991-1996 | Johns Hopkins |
| Stefania Pucciarelli | post-doc | 1995-1996 | Johns Hopkins |
BETA: Related publications
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Publications
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| Schön A, Freire E. (2020) Binding Thermodynamics to Intrinsically Disordered Protein Domains. Methods in Molecular Biology (Clifton, N.J.). 2141: 449-462 |
| Alsahafi N, Anand SP, Castillo-Menendez L, et al. (2018) SOSIP changes affect human immunodeficiency virus (HIV-1) envelope glycoprotein conformation and CD4 engagement. Journal of Virology |
| Herschhorn A, Gu C, Moraca F, et al. (2017) The β20-β21 of gp120 is a regulatory switch for HIV-1 Env conformational transitions. Nature Communications. 8: 1049 |
| Pancera M, Soumana D, Narpala S, et al. (2017) P-D3 Crystal structures of small-molecules HIV-1 entry ihibitor, BMS-378806 and BMS-626529, bound to BG505 SOSIP.664 HIV-1 Env trimer reveal an allosteric competitive etry inhibition mechanism Jaids Journal of Acquired Immune Deficiency Syndromes. 74: 90 |
| Schön A, Freire E. (2016) Enthalpy screen of drug candidates. Analytical Biochemistry. 513: 1-6 |
| Melillo B, Liang S, Park J, et al. (2016) Small-Molecule CD4-Mimics: Structure-Based Optimization of HIV-1 Entry Inhibition. Acs Medicinal Chemistry Letters. 7: 330-4 |
| Clarkson BR, Schön A, Freire E. (2016) Conformational stability and self-association equilibrium in biologics. Drug Discovery Today. 21: 342-7 |
| Chauhan J, Chen SE, Fenstermacher KJ, et al. (2015) Synthetic, structural mimetics of the β-hairpin flap of HIV-1 protease inhibit enzyme function. Bioorganic & Medicinal Chemistry |
| Do Kwon Y, Pancera M, Acharya P, et al. (2015) Crystal structure, conformational fixation and entry-related interactions of mature ligand-free HIV-1 Env. Nature Structural & Molecular Biology. 22: 522-31 |
| Velazquez-Campoy A, Leavitt SA, Freire E. (2015) Characterization of protein-protein interactions by isothermal titration calorimetry. Methods in Molecular Biology (Clifton, N.J.). 1278: 183-204 |