Brendan P. Eckelman, Ph.D.
Affiliations: | 2007 | Molecular Pathology | University of California, San Diego, La Jolla, CA |
Area:
Molecular Biology, PathologyGoogle:
"Brendan Eckelman"Mean distance: (not calculated yet)
Parents
Sign in to add mentor| Guy S. Salvesen | grad student | 2007 | UCSD | |
| (The regulation of caspase activity by inhibitor of apoptosis proteins.) | ||||
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Publications
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| Razai AS, Eckelman BP, Salvesen GS. (2020) Selective inhibition of matrix metalloproteinase 10 (MMP10) with a single-domain antibody. The Journal of Biological Chemistry |
| Barbee SD, Chen A, Johnson S, et al. (2017) Abstract 613: Development of FPA154, a novel tetravalent anti-GITR antibody, for the treatment of solid tumors Cancer Research. 77: 613-613 |
| Nakamura T, Wang L, Wong CC, et al. (2010) Transnitrosylation of XIAP regulates caspase-dependent neuronal cell death. Molecular Cell. 39: 184-95 |
| Eckelman BP, Drag M, Snipas SJ, et al. (2008) The mechanism of peptide-binding specificity of IAP BIR domains. Cell Death and Differentiation. 15: 920-8 |
| Denault JB, Eckelman BP, Shin H, et al. (2007) Caspase 3 attenuates XIAP (X-linked inhibitor of apoptosis protein)-mediated inhibition of caspase 9. The Biochemical Journal. 405: 11-9 |
| Eckelman BP, Salvesen GS, Scott FL. (2006) Human inhibitor of apoptosis proteins: why XIAP is the black sheep of the family. Embo Reports. 7: 988-94 |
| Eckelman BP, Salvesen GS. (2006) The human anti-apoptotic proteins cIAP1 and cIAP2 bind but do not inhibit caspases. The Journal of Biological Chemistry. 281: 3254-60 |
| Vucic D, Franklin MC, Wallweber HJ, et al. (2005) Engineering ML-IAP to produce an extraordinarily potent caspase 9 inhibitor: implications for Smac-dependent anti-apoptotic activity of ML-IAP. The Biochemical Journal. 385: 11-20 |
| Shin H, Renatus M, Eckelman BP, et al. (2005) The BIR domain of IAP-like protein 2 is conformationally unstable: implications for caspase inhibition. The Biochemical Journal. 385: 1-10 |