Darcy J. Bates, Ph.D.

Affiliations: 
2008 Wake Forest University, Winston-Salem, NC, United States 
Area:
Biochemistry, Molecular Biology
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"Darcy Bates"
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Charles S. Morrow grad student 2008 Wake Forest
 (Nitrolinoleic acid and nitro-oleic acid: Mechanisms of Nrf2 activation and modulation of PPARgamma-dependent bioactivity by multidrug resistance protein1 and glutathione S-transferases.)
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Publications

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Mallick DJ, Soderquist RS, Bates D, et al. (2019) Confounding off-target effects of BH3 mimetics at commonly used concentrations: MIM1, UMI-77, and A-1210477. Cell Death & Disease. 10: 185
Hampsch RA, Shee K, Bates D, et al. (2017) Therapeutic sensitivity to Rac GTPase inhibition requires consequential suppression of mTORC1, AKT, and MEK signaling in breast cancer. Oncotarget. 8: 21806-21817
Bates D, Feris EJ, Danilov AV, et al. (2016) Rapid induction of apoptosis in chronic lymphocytic leukemia cells by the microtubule disrupting agent BNC105. Cancer Biology & Therapy. 17: 291-9
Bates DJ, Danilov AV, Beaulieu BB, et al. (2013) Abstract 3522: Vincristine activates c-Jun N-terminal kinase in chronic lymphocytic leukemiain vivo. Cancer Research. 73: 3522-3522
Bates DJ, Smitherman PK, Townsend AJ, et al. (2011) Nitroalkene fatty acids mediate activation of Nrf2/ARE-dependent and PPARγ-dependent transcription by distinct signaling pathways and with significantly different potencies. Biochemistry. 50: 7765-73
Salerni BL, Bates DJ, Albershardt TC, et al. (2010) Vinblastine induces acute, cell cycle phase-independent apoptosis in some leukemias and lymphomas and can induce acute apoptosis in others when Mcl-1 is suppressed. Molecular Cancer Therapeutics. 9: 791-802
Bates DJ, Lively MO, Gorczynski MJ, et al. (2009) Noncatalytic interactions between glutathione S-transferases and nitroalkene fatty acids modulate nitroalkene-mediated activation of peroxisomal proliferator-activated receptor gamma. Biochemistry. 48: 4159-69
Alexander RL, Bates DJ, Wright MW, et al. (2006) Modulation of nitrated lipid signaling by multidrug resistance protein 1 (MRP1): glutathione conjugation and MRP1-mediated efflux inhibit nitrolinoleic acid-induced, PPARgamma-dependent transcription activation. Biochemistry. 45: 7889-96
Gorczynski M, Huang J, Alexander R, et al. (2006) P035. Regio- and stereospecific syntheses, nitric oxide donor properties, and PPARγ activity of (E)-9- and (E)-10-nitrooctadec-9-enoic acids Nitric Oxide. 14: 29
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