Kenneth Bastow

Affiliations: 
University of North Carolina, Chapel Hill, Chapel Hill, NC 
Area:
Organic Chemistry, Pharmaceutical Chemistry
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"Kenneth Bastow"
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Publications

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Xi W, Sun H, Bastow KF, et al. (2022) Identification of Novel 4'--Demethyl-epipodophyllotoxin Derivatives as Antitumor Agents Targeting Topoisomerase II. Molecules (Basel, Switzerland). 27
Wang XF, Ohkoshi E, Wang SB, et al. (2013) Synthesis and biological evaluation of N-alkyl-N-(4-methoxyphenyl)pyridin-2-amines as a new class of tubulin polymerization inhibitors. Bioorganic & Medicinal Chemistry. 21: 632-42
Wang Q, Chen TH, Bastow KF, et al. (2013) Songaricalarins A-E, cytotoxic oplopane sesquiterpenes from Ligularia songarica. Journal of Natural Products. 76: 305-10
Wang XF, Tian XT, Ohkoshi E, et al. (2012) Design and synthesis of diarylamines and diarylethers as cytotoxic antitumor agents. Bioorganic & Medicinal Chemistry Letters. 22: 6224-8
Yang X, Shi Q, Lai CY, et al. (2012) Antitumor agents 295. E-ring hydroxylated antofine and cryptopleurine analogues as antiproliferative agents: design, synthesis, and mechanistic studies. Journal of Medicinal Chemistry. 55: 6751-61
Hung HY, Ohkoshi E, Goto M, et al. (2012) Antitumor agents. 293. Nontoxic dimethyl-4,4'-dimethoxy-5,6,5',6'-dimethylenedioxybiphenyl-2,2'-dicarboxylate (DDB) analogues chemosensitize multidrug-resistant cancer cells to clinical anticancer drugs. Journal of Medicinal Chemistry. 55: 5413-24
Yen CT, Nakagawa-Goto K, Hwang TL, et al. (2012) Design and synthesis of gambogic acid analogs as potent cytotoxic and anti-inflammatory agents. Bioorganic & Medicinal Chemistry Letters. 22: 4018-22
Zhou T, Ohkoshi E, Shi Q, et al. (2012) Anti-AIDS agents 89. Identification of DCX derivatives as anti-HIV and chemosensitizing dual function agents to overcome P-gp-mediated drug resistance for AIDS therapy. Bioorganic & Medicinal Chemistry Letters. 22: 3219-22
Dong Y, Nakagawa-Goto K, Lai CY, et al. (2012) Antitumor agents. 289. Design, synthesis, and anti-breast cancer activity in vivo of 4-amino-2H-benzo[h]chromen-2-one and 4-amino-7,8,9,10-tetrahydro-2H-benzo[h]chromen-2-one analogues with improved water solubility. Journal of Natural Products. 75: 370-7
Wada K, Ohkoshi E, Morris-Natschke SL, et al. (2012) Cytotoxic esterified diterpenoid alkaloid derivatives with increased selectivity against a drug-resistant cancer cell line. Bioorganic & Medicinal Chemistry Letters. 22: 249-52
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