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Prashant J. Chikhale

Affiliations: 
University of Maryland School of Medicine, Baltimore, MD, United States 
Area:
Pharmaceutical Chemistry, Pharmacology
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"Prashant Chikhale"
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Dennis M. Killian grad student 2001 University of Maryland Medical School
Natthida Weerapreeyakul grad student 1998-2001 University of Maryland School of Pharmacy

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Publications

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Killian DM, Hermeling S, Chikhale PJ. (2007) Targeting the cerebrovascular large neutral amino acid transporter (LAT1) isoform using a novel disulfide-based brain drug delivery system. Drug Delivery. 14: 25-31
Rautioa J, Chikhale PJ. (2004) Drug delivery systems for brain tumor therapy. Current Pharmaceutical Design. 10: 1341-53
Killian DM, Chikhale PJ. (2001) Predominant functional activity of the large, neutral amino acid transporter (LAT1) isoform at the cerebrovasculature. Neuroscience Letters. 306: 1-4
Gharat L, Taneja R, Weerapreeyakul N, et al. (2001) Targeted drug delivery systems 6: Intracellular bioreductive activation, uptake and transport of an anticancer drug delivery system across intestinal Caco-2 cell monolayers. International Journal of Pharmaceutics. 219: 1-10
Killian DM, Chikhale PJ. (2001) A bioreversible prodrug approach designed to shift mechanism of brain uptake for amino-acid-containing anticancer agents. Journal of Neurochemistry. 76: 966-74
Weerapreeyakul N, Hollenbeck RG, Chikhale PJ. (2000) Stability of bioreductive drug delivery systems containing melphalan is influenced by conformational constraint and electronic properties of substituents. Bioorganic & Medicinal Chemistry Letters. 10: 2391-5
Killian DM, Gharat L, Chikhale PJ. (2000) Modulating blood-brain barrier interactions of amino acid-based anticancer agents. Drug Delivery. 7: 21-5
Weerapreeyakul N, Visser P, Brummelhuis M, et al. (2000) Reductive and bioreductive activation is controlled by electronic properties of substituents in conformationally-constrained anticancer drug delivery systems Medicinal Chemistry Research. 10: 149-163
Chikhale EG, Chikhale PJ, Borchardt RT. (1995) Carrier-mediated transport of the antitumor agent acivicin across the blood-brain barrier Biochemical Pharmacology. 49: 941-945
Audus KL, Chikhale PJ, Miller DW, et al. (1992) Brain uptake of drugs: The influence of chemical and biological factors Advances in Drug Research. 23: 1-64
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