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Michael Doughty

Affiliations: 
University of Kansas, Lawrence, KS, United States 
Area:
Pharmaceutical Chemistry
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"Michael Doughty"
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Parents

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Gerald E. Risinger grad student 1978-1982 Louisiana State
Emil Thomas Kaiser post-doc 1983-1987 Rockefeller

Children

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Longqin Hu grad student 1988-1993 University of Kansas
Weiying Lin grad student 2000 University of Kansas

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Publications

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Doughty MB, Aboudehen K, Anderson G, et al. (2004) Side-chain conformational restriction in template-competitive inhibitors of E. coli DNA polymerase I Klenow fragment: synthesis, structural characterization and inhibition activity. Nucleosides, Nucleotides & Nucleic Acids. 23: 1751-65
Lin W, Li K, Moore BM, et al. (2003) Conformational properties of nucleotide-based template-competitive HIV-1 reverse transcriptase inhibitors: analysis of enzyme binding modes. Nucleosides, Nucleotides & Nucleic Acids. 22: 283-97
Lin W, Li K, Doughty MB. (2002) Characterization of a binding site for template competitive inhibitors of HIV-1 reverse transcriptase using photolabeling derivatives. Bioorganic & Medicinal Chemistry. 10: 4131-41
Li K, Lin W, Chong KH, et al. (2002) Template-competitive inhibitors of HIV-1 reverse transcriptase: design, synthesis and inhibitory activity. Bioorganic & Medicinal Chemistry. 10: 507-15
Hu L, Doughty MB. (1994) Neuropeptide Y acylation chemistry in aqueous solution: significance to synthesis of a peptide-based photoaffinity label. Journal of Protein Chemistry. 13: 135-40
Hu L, Balse P, Doughty MB. (1994) Neuropeptide Y N-terminal deletion fragments: correlation between solution structure and receptor binding activity at Y1 receptors in rat brain cortex. Journal of Medicinal Chemistry. 37: 3622-9
Doughty MB, Hu L. (1993) The contribution of helical potential to the in vitro receptor binding activity of a neuropeptide Y N-terminal deletion fragment. Biopolymers. 33: 1195-206
Doughty MB, Chaurasia CS, Li K. (1993) Benextramine-neuropeptide Y receptor interactions: contribution of the benzylic moieties to [3H]neuropeptide Y displacement activity. Journal of Medicinal Chemistry. 36: 272-9
Mobashery S, Doughty M, Kaiser ET. (1990) Inactivation of the catalytic subunit of bovine cAMP-dependent protein kinase by a peptide-based affinity inactivator. Biopolymers. 29: 131-8
DOUGHTY MB, LAWRENCE DS. (1985) ChemInform Abstract: ON THE INTRAMOLECULAR CYCLIZATION OF A THIAZOLIUM SALT Chemischer Informationsdienst. 16
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