☰ Chemistry Tree

Jaap Brouwer

Affiliations:

Leiden University, Leiden, Netherlands

Area:

Molecular genetics

Website:

http://www.leidenuniv.nl/professoren/show_en.php3-medewerker_id=728.htm

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Mean distance: 12.79

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Parents

Pieter van de Putte	grad student	1988	Leiden
(Mutation induction by cis platinum-compounds in Escherichia coli)

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Publications

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Vermeij WP, Florea BI, Isenia S, et al. (2012) Proteomic identification of in vivo interactors reveals novel function of skin cornification proteins. Journal of Proteome Research. 11: 3068-76
Marqués-Gallego P, Contaldi S, den Dulk H, et al. (2009) Relevance of the leaving group for antitumor activity of new platinum(II) compounds containing anthracene derivatives as a carrier ligand. Journal of Inorganic Biochemistry. 103: 1602-8
Marqués-Gallego P, den Dulk H, Brouwer J, et al. (2009) Cytotoxic activity and cellular processing in human ovarian carcinoma cell lines of a new platinum(II) compound containing a fluorescent substituted propylene diamine ligand. Biochemical Pharmacology. 78: 365-73
Marqués-Gallego P, Kalayda GV, Jaehde U, et al. (2009) Cellular accumulation and DNA platination of two new platinum(II) anticancer compounds based on anthracene derivatives as carrier ligands. Journal of Inorganic Biochemistry. 103: 791-6
den Dulk B, van Eijk P, de Ruijter M, et al. (2008) The NER protein Rad33 shows functional homology to human Centrin2 and is involved in modification of Rad4. Dna Repair. 7: 858-68
den Dulk B, Sun SM, de Ruijter M, et al. (2006) Rad33, a new factor involved in nucleotide excision repair in Saccharomyces cerevisiae. Dna Repair. 5: 683-92
van Rijt S, van Zutphen S, den Dulk H, et al. (2006) Structure-activity relationship studies for three new asymmetric cis-platinum(II) aminoethanol-based complexes Inorganica Chimica Acta. 359: 4125-4129
Backendorf C, de Wit J, van Oosten M, et al. (2005) Repair characteristics and differentiation propensity of long-term cultures of epidermal keratinocytes derived from normal and NER-deficient mice. Dna Repair. 4: 1325-36
den Dulk B, Brandsma JA, Brouwer J. (2005) The Rad4 homologue YDR314C is essential for strand-specific repair of RNA polymerase I-transcribed rDNA in Saccharomyces cerevisiae. Molecular Microbiology. 56: 1518-26
van Waardenburg RC, de Jong LA, van Delft F, et al. (2004) Homologous recombination is a highly conserved determinant of the synergistic cytotoxicity between cisplatin and DNA topoisomerase I poisons. Molecular Cancer Therapeutics. 3: 393-402

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