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Linda O. Tremblay, Ph.D.

Affiliations: 
2002 McGill University, Montreal, QC, Canada 
Area:
Biochemistry, Molecular Biology
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Annette Herscovics grad student 2002 McGill
 (Characterization of human class I alpha1,2-mannosidases involved in N-glycan biosynthesis and the role of murine alpha1,2-mannosidase IB in embryogenesis and development.)

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Publications

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Hosokawa N, Tremblay LO, Sleno B, et al. (2010) EDEM1 accelerates the trimming of alpha1,2-linked mannose on the C branch of N-glycans. Glycobiology. 20: 567-75
Hosokawa N, You Z, Tremblay LO, et al. (2007) Stimulation of ERAD of misfolded null Hong Kong alpha1-antitrypsin by Golgi alpha1,2-mannosidases. Biochemical and Biophysical Research Communications. 362: 626-32
Tremblay LO, Nagy Kovács E, Daniels E, et al. (2007) Respiratory distress and neonatal lethality in mice lacking Golgi alpha1,2-mannosidase IB involved in N-glycan maturation. The Journal of Biological Chemistry. 282: 2558-66
Hirao K, Natsuka Y, Tamura T, et al. (2006) EDEM3, a soluble EDEM homolog, enhances glycoprotein endoplasmic reticulum-associated degradation and mannose trimming. The Journal of Biological Chemistry. 281: 9650-8
Hosokawa N, Tremblay LO, You Z, et al. (2003) Enhancement of endoplasmic reticulum (ER) degradation of misfolded Null Hong Kong alpha1-antitrypsin by human ER mannosidase I. The Journal of Biological Chemistry. 278: 26287-94
Herscovics A, Romero PA, Tremblay LO. (2002) The specificity of the yeast and human class I ER alpha 1,2-mannosidases involved in ER quality control is not as strict previously reported. Glycobiology. 12: 14G-15G
Hosokawa N, Wada I, Hasegawa K, et al. (2001) A novel ER alpha-mannosidase-like protein accelerates ER-associated degradation. Embo Reports. 2: 415-22
Tremblay LO, Herscovics A. (2000) Characterization of a cDNA encoding a novel human Golgi alpha 1, 2-mannosidase (IC) involved in N-glycan biosynthesis. The Journal of Biological Chemistry. 275: 31655-60
Tremblay LO, Herscovics A. (1999) Cloning and expression of a specific human alpha 1,2-mannosidase that trims Man9GlcNAc2 to Man8GlcNAc2 isomer B during N-glycan biosynthesis. Glycobiology. 9: 1073-8
Tremblay LO, Campbell Dyke N, Herscovics A. (1998) Molecular cloning, chromosomal mapping and tissue-specific expression of a novel human alpha1,2-mannosidase gene involved in N-glycan maturation. Glycobiology. 8: 585-95
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