Michael D. Staake, Ph.D.
Affiliations: | 2004 | University of California, San Diego, La Jolla, CA |
Area:
Organic Chemistry, Biochemistry, Oncology, Pharmaceutical ChemistryGoogle:
"Michael Staake"Mean distance: (not calculated yet)
Parents
Sign in to add mentor| Trevor C. McMorris | grad student | 2004 | UCSD | |
| (1. Total asymmetric synthesis of irofulven; 2. Peptide conjugate prodrugs of irofulven.) | ||||
| Steven E Patterson | post-doc | UMN | ||
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Publications
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| Staake MD, Kashinatham A, McMorris TC, et al. (2016) Hydroxyurea derivatives of irofulven with improved antitumor efficacy. Bioorganic & Medicinal Chemistry Letters. 26: 1836-8 |
| Staake M, Chauhan J, Zhou D, et al. (2010) Phosphonoxins III: synthesis of α-aminophosphonate analogs of antifungal polyoxins with anti-Giardia activity. Organic Letters. 12: 4596-9 |
| McMorris TC, Chimmani R, Alisala K, et al. (2010) Structure-activity studies of urea, carbamate, and sulfonamide derivatives of acylfulvene. Journal of Medicinal Chemistry. 53: 1109-16 |
| Zhou D, Staake M, Patterson SE. (2008) Phosphonoxins II: Diastereoselective synthesis of phosphonic acid analogues of polyoxins Organic Letters. 10: 2179-2182 |
| McMorris TC, Chimmani R, Gurram M, et al. (2007) Synthesis and antitumor activity of amine analogs of irofulven. Bioorganic & Medicinal Chemistry Letters. 17: 6770-2 |
| McMorris TC, Staake MD, Kelner MJ. (2004) Synthesis and biological activity of enantiomers of antitumor irofulven. The Journal of Organic Chemistry. 69: 619-23 |
| McMorris TC, Staake MD. (2002) Resolution of both enantiomers of 5-chloro-5-methyl-2-cyclopentenone. The Journal of Organic Chemistry. 67: 7902-3 |