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Roy J. Duhe

Affiliations: 
The University of Mississippi Medical Center, Jackson, MS, United States 
Area:
Pharmacology, Biochemistry, Molecular Biology
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"Roy Duhe"
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Parents

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Bruce R. Selman grad student 1984-1985 UW Madison

Children

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Kiranam Chatti grad student 2000-2004 University of Mississippi Medical Center
Sheeyong Lee grad student 2000-2007 University of Mississippi Medical Center
John K. Smith grad student 2003-2008 University of Mississippi Medical Center
Kanakadurga Kundrapu grad student 2001-2009 University of Mississippi Medical Center
Chetan N. Patil grad student 2008-2012 University of Mississippi Medical Center
Naila M. Mamoon post-doc 2002-2005 University of Mississippi Medical Center (Physics Tree)

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Publications

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Zouein FA, Duhé RJ, Arany I, et al. (2014) Loss of STAT3 in mouse embryonic fibroblasts reveals its Janus-like actions on mitochondrial function and cell viability. Cytokine. 66: 7-16
Duhé RJ. (2013) Redox regulation of Janus kinase: The elephant in the room. Jak-Stat. 2: e26141
Kurdi M, Sivakumaran V, Duhé RJ, et al. (2012) Depletion of cellular glutathione modulates LIF-induced JAK1-STAT3 signaling in cardiac myocytes. The International Journal of Biochemistry & Cell Biology. 44: 2106-15
Smith JK, Patil CN, Patlolla S, et al. (2012) Identification of a redox-sensitive switch within the JAK2 catalytic domain. Free Radical Biology & Medicine. 52: 1101-10
Zouein FA, Duhé RJ, Booz GW. (2011) JAKs go nuclear: emerging role of nuclear JAK1 and JAK2 in gene expression and cell growth. Growth Factors (Chur, Switzerland). 29: 245-52
Kundrapu K, Colenberg L, Duhé RJ. (2008) Activation loop tyrosines allow the JAK2(V617F) mutant to attain hyperactivation. Cell Biochemistry and Biophysics. 52: 103-12
Mamoon NM, Smith JK, Chatti K, et al. (2007) Multiple cysteine residues are implicated in Janus kinase 2-mediated catalysis. Biochemistry. 46: 14810-8
Lee S, Duhé RJ. (2006) Kinase activity and subcellular distribution of a chimeric green fluorescent protein-tagged Janus kinase 2. Journal of Biomedical Science. 13: 773-86
Chatti K, Farrar WL, Duhé RJ. (2004) Tyrosine phosphorylation of the Janus kinase 2 activation loop is essential for a high-activity catalytic state but dispensable for a basal catalytic state. Biochemistry. 43: 4272-83
Smith JK, Mamoon NM, Duhé RJ. (2004) Emerging roles of targeted small molecule protein-tyrosine kinase inhibitors in cancer therapy. Oncology Research. 14: 175-225
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