Angela M. Lam, Ph.D.
Affiliations: | 2001 | University of British Columbia, Vancouver, Vancouver, BC, Canada |
Area:
Biochemistry, Molecular BiologyGoogle:
"Angela Lam"Mean distance: (not calculated yet)
Parents
Sign in to add mentor| Pieter R. Cullis | grad student | 2001 | UBC | |
| (Influence of calcium on the transfection properties of lipid-based gene delivery systems.) | ||||
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Publications
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| Lam AM, Dugyala RR, Sheraz M, et al. (2024) Preclinical Antiviral and Safety Profiling of the HBV RNA Destabilizer AB-161. Viruses. 16 |
| Zhao Q, Chang J, Rijnbrand R, et al. (2022) Pregenomic RNA Launch Hepatitis B Virus Replication System Facilitates the Mechanistic Study of Antiviral Agents and Drug-Resistant Variants on Covalently Closed Circular DNA Synthesis. Journal of Virology. e0115022 |
| Hartman GD, Kuduk SD, Espiritu C, et al. (2020) 450s nder striction (PURE) Screen Using HepaRG and Primary Human Hepatocytes for Discovery of Novel HBV Antivirals. Acs Medicinal Chemistry Letters. 11: 1919-1927 |
| Kuduk SD, Lam AM, Espiritu C, et al. (2019) SAR studies in the sulfonyl carboxamide class of HBV capsid assembly modulators. Bioorganic & Medicinal Chemistry Letters |
| Lam AM, Espiritu C, Vogel R, et al. (2018) Preclinical Characterization of NVR 3-778, a First-in-Class Capsid Assembly Modulator Against the Hepatitis B Virus. Antimicrobial Agents and Chemotherapy |
| Klumpp K, Shimada T, Allweiss L, et al. (2017) Efficacy of NVR 3-778, Alone and in Combination With Pegylated Interferon, vs Entecavir in uPA/SCID Mice With Humanized Livers and HBV Infection. Gastroenterology |
| Lam AM, Ren S, Espiritu C, et al. (2017) HBV Capsid Assembly Modulators, but not Nucleoside Analogs, Inhibit the Production of Extracellular Pregenomic RNA and Spliced RNA Variants. Antimicrobial Agents and Chemotherapy |
| Klumpp K, Lam AM, Lukacs C, et al. (2015) High-resolution crystal structure of a hepatitis B virus replication inhibitor bound to the viral core protein. Proceedings of the National Academy of Sciences of the United States of America |
| Lam A, Espiritu C, Flores O, et al. (2015) P0640 : Effect of the combination of the HBV core inhibitor NVR 3-778 with nucleoside analogs or other HBV core inhibitors on the inhibition of HBV DNA replication in HepG2.2.15 cells Journal of Hepatology. 62 |
| Klumpp K, Shimada T, Allweiss L, et al. (2015) O115 : High antiviral activity of the HBV core inhibitor NVR 3-778 in the humanized uPA/SCID mouse model Journal of Hepatology. 62: S250 |