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Roselyne Castonguay, Ph.D.

Affiliations: 
2004 Université de Montréal, Montréal, Canada 
Area:
Organic Chemistry
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Parents

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Jeffrey W. Keillor grad student 2004 Université de Montréal
 (Etudes cinetiques de la gamma-glutamyltranspeptidase purifiee de reins de rat et recombinante humaine provenant des levures Pichia pastoris.)

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Publications

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Castonguay R, Werner ED, Matthews RG, et al. (2011) Soluble endoglin specifically binds bone morphogenetic proteins 9 and 10 via its orphan domain, inhibits blood vessel formation, and suppresses tumor growth. The Journal of Biological Chemistry. 286: 30034-46
Guy J, Castonguay R, Campos-Reales Pineda NB, et al. (2010) De novo helical peptides as target sequences for a specific, fluorogenic protein labelling strategy. Molecular Biosystems. 6: 976-87
Castonguay R, Halim D, Morin M, et al. (2007) Kinetic characterization and identification of the acylation and glycosylation sites of recombinant human gamma-glutamyltranspeptidase. Biochemistry. 46: 12253-62
Castonguay R, He W, Chen AY, et al. (2007) Stereospecificity of ketoreductase domains of the 6-deoxyerythronolide B synthase. Journal of the American Chemical Society. 129: 13758-69
Keillor JW, Castonguay R, Lherbet C. (2005) Gamma-glutamyl transpeptidase substrate specificity and catalytic mechanism. Methods in Enzymology. 401: 449-67
Lherbet C, Castonguay R, Keillor JW. (2005) Transesterification of trialkyl phosphates from alkyl bromides Tetrahedron Letters. 46: 3565-3567
Keillor JW, Ménard A, Castonguay R, et al. (2004) Pre-steady-state kinetic studies of rat kidneyγ-glutamyl transpeptidase confirm its ping-pong mechanism Journal of Physical Organic Chemistry. 17: 529-536
Castonguay R, Lherbet C, Keillor JW. (2003) Kinetic studies of rat kidney gamma-glutamyltranspeptidase deacylation reveal a general base-catalyzed mechanism. Biochemistry. 42: 11504-13
Lherbet C, Morin M, Castonguay R, et al. (2003) Synthesis of aza and oxaglutamyl-p-nitroanilide derivatives and their kinetic studies with gamma-glutamyltranspeptidase. Bioorganic & Medicinal Chemistry Letters. 13: 997-1000
Keillor JW, Lherbet C, Castonguay R, et al. (2003) Expression, purification, crystallization and preliminary crystallographic analysis of Trypanosoma brucei phosphofructokinase. Acta Crystallographica. Section D, Biological Crystallography. 59: 532-4
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