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Les Hanakahi

Affiliations: 
Johns Hopkins University, Baltimore, MD 
Area:
Biochemistry, Molecular Biology
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"Les Hanakahi"
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Joyce C. Cheung grad student 2008 Johns Hopkins

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Hanakahi L. (2011) Effect of the inositol polyphosphate InsP(6) on DNA-PK-dependent phosphorylation. Molecular Cancer Research : McR. 9: 1366-76
Killen MW, Stults DM, Adachi N, et al. (2009) Loss of Bloom syndrome protein destabilizes human gene cluster architecture. Human Molecular Genetics. 18: 3417-28
Jayaram S, Gilson T, Ehrlich ES, et al. (2008) E1B 55k-independent dissociation of the DNA ligase IV/XRCC4 complex by E4 34k during adenovirus infection. Virology. 382: 163-70
Jayaram S, Ketner G, Adachi N, et al. (2008) Loss of DNA ligase IV prevents recognition of DNA by double-strand break repair proteins XRCC4 and XLF. Nucleic Acids Research. 36: 5773-86
Cheung JC, Salerno B, Hanakahi LA. (2008) Evidence for an inositol hexakisphosphate-dependent role for Ku in mammalian nonhomologous end joining that is independent of its role in the DNA-dependent protein kinase. Nucleic Acids Research. 36: 5713-26
Mason TM, Smeaton MB, Cheung JC, et al. (2008) End modification of a linear DNA duplex enhances NER-mediated excision of an internal Pt(II)-lesion. Bioconjugate Chemistry. 19: 1064-70
Smeaton MB, Miller PS, Ketner G, et al. (2007) Small-scale extracts for the study of nucleotide excision repair and non-homologous end joining. Nucleic Acids Research. 35: e152
Rubin E, Wu X, Zhu T, et al. (2007) A role for the HOXB7 homeodomain protein in DNA repair. Cancer Research. 67: 1527-35
Hanakahi LA. (2007) 2-Step purification of the Ku DNA repair protein expressed in Escherichia coli. Protein Expression and Purification. 52: 139-45
Cheung JC, Hanakahi LA. (2007) The requirement of a Ku‐IP6 (inositol hexakisphosphate) complex for efficient repair of DNA double strand breaks by non‐homologous end joining in mammals The Faseb Journal. 21
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