Heinz G. Floss, Ph.D.

Affiliations: 
1966-1982 Chemistry Purdue University, West Lafayette, IN, United States 
 1982-1987 Chemistry Ohio State University, Columbus, Columbus, OH 
 1988- University of Washington, Seattle, Seattle, WA 
Area:
biosynthesis of antibiotics and related natural products
Website:
http://depts.washington.edu/chem/people/faculty/floss.html
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Publications

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Rui Z, Ye M, Wang S, et al. (2012) Insights into a divergent phenazine biosynthetic pathway governed by a plasmid-born esmeraldin gene cluster. Chemistry & Biology. 19: 1116-25
Eichner S, Eichner T, Floss HG, et al. (2012) Broad substrate specificity of the amide synthase in S. hygroscopicus--new 20-membered macrolactones derived from geldanamycin. Journal of the American Chemical Society. 134: 1673-9
Eichner S, Knobloch T, Floss HG, et al. (2012) The interplay between mutasynthesis and semisynthesis: generation and evaluation of an ansamitocin library. Angewandte Chemie (International Ed. in English). 51: 752-7
Wu Y, Kang Q, Shang G, et al. (2011) N-methylation of the amide bond by methyltransferase asm10 in ansamitocin biosynthesis. Chembiochem : a European Journal of Chemical Biology. 12: 1759-66
Floss HG, Yu TW, Arakawa K. (2011) The biosynthesis of 3-amino-5-hydroxybenzoic acid (AHBA), the precursor of mC7N units in ansamycin and mitomycin antibiotics: a review. The Journal of Antibiotics. 64: 35-44
Harmrolfs K, Brünjes M, Dräger G, et al. (2010) Cyclization of synthetic seco-proansamitocins to ansamitocin macrolactams by Actinosynnema pretiosum as biocatalyst. Chembiochem : a European Journal of Chemical Biology. 11: 2517-20
Rui Z, Petrícková K, Skanta F, et al. (2010) Biochemical and genetic insights into asukamycin biosynthesis. The Journal of Biological Chemistry. 285: 24915-24
Floss H, Leistner E. (2010) Obituary – Professor Dr. Detlef Gröger Planta Medica. 76: 1389-1389
Hu Y, Floss HG. (2010) ChemInform Abstract: New Type II Manumycins Produced by Streptomyces nodosus ssp. asukaensis and Their Biosynthesis. Cheminform. 32: no-no
Eichner S, Floss HG, Sasse F, et al. (2009) New, highly active nonbenzoquinone geldanamycin derivatives by using mutasynthesis. Chembiochem : a European Journal of Chemical Biology. 10: 1801-5
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