Shan Zha, Ph.D.

Affiliations: 
1998-2004 Pharmacology and Molecular Sciences Johns Hopkins University, Baltimore, MD 
 2004-2009 Molecular Genetics Harvard - Boston Children's Hospital 
 2009- Institute for Cancer Genetics Columbia University College of Physicians and Surgeons, New York, NY, United States 
Area:
DNA repair, Oncology, Molecular Biology, Pharmacology
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"Shan Zha"
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Parents

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William B. Isaacs grad student 1998-2004 Johns Hopkins
 (Cyclooxygenase-2 and alpha-methylacyl-CoA racemase in prostate cancer.)
Frederick W. Alt post-doc 2004-2009 Harvard - Boston Children's Hospital
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Publications

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Wu-Baer F, Wong M, Tschoe L, et al. (2023) ATM/ATR Phosphorylation of CtIP on Its Conserved Sae2-like Domain Is Required for Genotoxin-Induced DNA Resection but Dispensable for Animal Development. Cells. 12
Li Z, Duan S, Hua X, et al. (2023) Asymmetric distribution of parental H3K9me3 in S phase silences L1 elements. Nature. 623: 643-651
Cimprich KA, Li GM, Demaria S, et al. (2023) The crosstalk between DNA repair and immune responses. Molecular Cell. 83: 3582-3587
Shao Z, Lee BJ, Zhang H, et al. (2023) Inactive PARP1 causes embryonic lethality and genome instability in a dominant-negative manner. Proceedings of the National Academy of Sciences of the United States of America. 120: e2301972120
Menolfi D, Lee BJ, Zhang H, et al. (2023) ATR kinase supports normal proliferation in the early S phase by preventing replication resource exhaustion. Nature Communications. 14: 3618
Schvartzman JM, Forsyth G, Walch H, et al. (2023) Oncogenic IDH mutations increase heterochromatin-related replication stress without impacting homologous recombination. Molecular Cell
Zhu Y, Jiang W, Lee BJ, et al. (2023) Phosphorylation of DNA-PKcs at the S2056 cluster ensures efficient and productive lymphocyte development in XLF-deficient mice. Proceedings of the National Academy of Sciences of the United States of America. 120: e2221894120
Menolfi D, Lee BJ, Zhang H, et al. (2023) ATR kinase supports normal proliferation in the early S phase by preventing replication resource exhaustion. Biorxiv : the Preprint Server For Biology
Zagelbaum J, Schooley A, Zhao J, et al. (2023) Author Correction: Multiscale reorganization of the genome following DNA damage facilitates chromosome translocations via nuclear actin polymerization. Nature Structural & Molecular Biology
Langelier MF, Lin X, Zha S, et al. (2023) Clinical PARP inhibitors allosterically induce PARP2 retention on DNA. Science Advances. 9: eadf7175
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