Christina L. Kline, Ph.D.
Affiliations: | 2011 | Pennsylvania State University, State College, PA, United States |
Area:
Molecular Biology, Biochemistry, OncologyGoogle:
"Christina Kline"Mean distance: (not calculated yet)
Parents
Sign in to add mentor| Rosalyn B. Irby | grad student | 2011 | Penn State | |
| (Potential of prostate apoptosis response protein-4 (Par-4) in colon cancer therapy.) | ||||
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Publications
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| Wagner J, Kline CL, Zhou L, et al. (2018) Dose intensification of TRAIL-inducing ONC201 inhibits metastasis and promotes intratumoral NK cell recruitment. The Journal of Clinical Investigation |
| Wagner J, Kline CL, Ralff MD, et al. (2017) Preclinical evaluation of the imipridone family, analogues of clinical stage anti-cancer small molecule ONC201, reveals potent anti-cancer effects of ONC212. Cell Cycle (Georgetown, Tex.). 0 |
| Allen JE, Kline CL, Prabhu VV, et al. (2016) Discovery and clinical introduction of first-in-class imipridone ONC201. Oncotarget |
| Kline CL, Van den Heuvel AP, Allen JE, et al. (2016) ONC201 kills solid tumor cells by triggering an integrated stress response dependent on ATF4 activation by specific eIF2α kinases. Science Signaling. 9: ra18 |
| Prabhu VV, Lulla A, Kline CL, et al. (2016) Single Agent and Combinatorial Efficacy of First-in-Class Small Molecule ONC201 in Acute Leukemia and Multiple Myeloma Blood. 128: 2759-2759 |
| Zhang S, Zhou L, Hong B, et al. (2015) Small-Molecule NSC59984 Restores p53 Pathway Signaling and Antitumor Effects against Colorectal Cancer via p73 Activation and Degradation of Mutant p53. Cancer Research. 75: 3842-52 |
| Kline CL, Heuvel Pvd, Allen JE, et al. (2015) Abstract 674: Early integrated stress response induction of ATF4 is required for the anticancer effects of the dual Akt/ERK inhibitor and TRAIL pathway inducer ONC201/TIC10 Cancer Research. 75: 674-674 |
| Wagner J, Kline CL, Pottorf RS, et al. (2015) Abstract 4499: Cytotoxicity, biochemical activity, and structural analysis of ONC201 and comparisons to a biologically inactive isomer Cancer Research. 75: 4499-4499 |
| Kline CL, Lulla AR, Dicker D, et al. (2015) Abstract 2942: TRAIL pathway inducer ONC201/TIC10 primes multiple myeloma cells (MM) for apoptosis by downregulating X-linked inhibitor of apoptosis Cancer Research. 75: 2942-2942 |
| Wagner J, Kline CL, Pottorf RS, et al. (2014) The angular structure of ONC201, a TRAIL pathway-inducing compound, determines its potent anti-cancer activity. Oncotarget. 5: 12728-37 |