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James J. Manfredi

Affiliations: 
Cancer Biology Icahn School of Medicine at Mount Sinai, New York, NY, United States 
Area:
Oncology, Biochemistry, Molecular Biology, Cell Biology
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"James Manfredi"
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Children

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Edward C. Thornborrow grad student 2001 Mount Sinai School of Medicine
Selvon St. Clair grad student 2002 Mount Sinai School of Medicine
Luciana E. Giono grad student 2006 Mount Sinai School of Medicine
Dana J. Lukin grad student 2006 Mount Sinai School of Medicine
Luis A. Carvajal grad student 2012 Mount Sinai
Crystal A. Tonnessen grad student 2013 Mount Sinai School of Medicine

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Publications

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Efe G, Dunbar KJ, Sugiura K, et al. (2023) p53 gain-of-function mutation induces metastasis via Brd4-dependent Csf-1 expression. Cancer Discovery
Su Z, Kon N, Yi J, et al. (2023) Specific regulation of BACH1 by the hotspot mutant p53 reveals a distinct gain-of-function mechanism. Nature Cancer
Resnick-Silverman L, Zhou R, Campbell MJ, et al. (2023) In vivo RNA-seq and ChIP-seq analyses show an obligatory role for the C terminus of p53 in conferring tissue-specific radiation sensitivity. Cell Reports. 42: 112216
Tong DR, Zhou W, Katz C, et al. (2021) p53 frameshift mutations couple loss-of-function with unique neomorphic activities. Molecular Cancer Research : McR
Manfredi JJ. (2021) Mdm2 and MdmX: Partners in p53 Destruction. Cancer Research. 81: 1633-1634
Farkas M, Hashimoto H, Bi Y, et al. (2021) Distinct mechanisms control genome recognition by p53 at its target genes linked to different cell fates. Nature Communications. 12: 484
Kon N, Churchill M, Li H, et al. (2020) Robust p53 stabilization is dispensable for its activation and tumor suppressor function. Cancer Research
Manfredi JJ. (2019) p53 defies convention again: a p53 mutant that has lost tumor suppression but still can kill. The Embo Journal. e103322
Manfredi JJ. (2019) Inactivation of Wild-Type p53 by Asparagine Endopeptidase in Glioblastoma: An Opportunity to Target the "Undruggable". Journal of the National Cancer Institute
Manfredi JJ. (2019) p53 and Development: Shedding Light on an Evolutionary Enigma. Developmental Cell. 50: 128-129
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