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Anthony R. Cyr, Ph.D.

Affiliations: 
2014 Free Radical and Radiation Biology University of Iowa, Iowa City, IA 
Area:
Molecular Biology, Biochemistry, Oncology
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Frederick E. Domann grad student 2014 University of Iowa
 (Transcription factor activator protein 2C and downstream redox biology effectors in development and carcinogenesis.)

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Publications

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Park JM, Wu T, Cyr AR, et al. (2015) The role of Tcfap2c in tumorigenesis and cancer growth in an activated Neu model of mammary carcinogenesis. Oncogene
Cyr AR, Kulak MV, Park JM, et al. (2015) TFAP2C governs the luminal epithelial phenotype in mammary development and carcinogenesis. Oncogene. 34: 436-44
Bogachek MV, Chen Y, Kulak MV, et al. (2014) Sumoylation pathway is required to maintain the basal breast cancer subtype. Cancer Cell. 25: 748-61
Spanheimer PM, Park JM, Askeland RW, et al. (2014) Inhibition of RET increases the efficacy of antiestrogen and is a novel treatment strategy for luminal breast cancer Clinical Cancer Research. 20: 2115-2125
Spanheimer PM, Cyr AR, Gillum MP, et al. (2014) Distinct pathways regulated by RET and estrogen receptor in luminal breast cancer demonstrate the biological basis for combination therapy. Annals of Surgery. 259: 793-9
Park JM, Wu T, Woodfield G, et al. (2014) Abstract 3914: Tcfap2c regulates growth and oncogenesis in neu-activated breast cancer Cancer Research. 74: 3914-3914
Cyr AR, Kulak MV, Park JM, et al. (2014) TFAP2C governs the luminal epithelial phenotype in mammary development and carcinogenesis Oncogene
Cyr AR, Brown KE, McCormick ML, et al. (2013) Maintenance of mitochondrial genomic integrity in the absence of manganese superoxide dismutase in mouse liver hepatocytes. Redox Biology. 1: 172-7
Kulak MV, Cyr AR, Woodfield GW, et al. (2013) Transcriptional regulation of the GPX1 gene by TFAP2C and aberrant CpG methylation in human breast cancer. Oncogene. 32: 4043-51
Cyr AR, Hitchler MJ, Domann FE. (2013) Regulation of SOD2 in cancer by histone modifications and CpG methylation: closing the loop between redox biology and epigenetics. Antioxidants & Redox Signaling. 18: 1946-55
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