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Sarah D. Lamore, Ph.D.

Affiliations: 
2012 Pharmacology & Toxicology University of Arizona, Tucson, AZ 
Area:
Pharmacy, Pharmacology, Toxicology
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Georg T. Wondrak grad student 2012 University of Arizona
 (Identification of cathepsin B and L as novel UVA targets upstream of cutaneous lysosomal-autophagic dysregulation.)

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Publications

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Lamore SD, Wondrak GT. (2013) UVA causes dual inactivation of cathepsin B and L underlying lysosomal dysfunction in human dermal fibroblasts. Journal of Photochemistry and Photobiology. B, Biology. 123: 1-12
Qiao S, Cabello CM, Lamore SD, et al. (2012) D-Penicillamine targets metastatic melanoma cells with induction of the unfolded protein response (UPR) and Noxa (PMAIP1)-dependent mitochondrial apoptosis. Apoptosis : An International Journal On Programmed Cell Death. 17: 1079-94
Qiao S, Lamore SD, Cabello CM, et al. (2012) Thiostrepton is an inducer of oxidative and proteotoxic stress that impairs viability of human melanoma cells but not primary melanocytes. Biochemical Pharmacology. 83: 1229-40
Lamore SD, Wondrak GT. (2012) Autophagic-lysosomal dysregulation downstream of cathepsin B inactivation in human skin fibroblasts exposed to UVA. Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society For Photobiology. 11: 163-72
Cabello CM, Lamore SD, Bair WB, et al. (2012) The redox antimalarial dihydroartemisinin targets human metastatic melanoma cells but not primary melanocytes with induction of NOXA-dependent apoptosis. Investigational New Drugs. 30: 1289-301
Lamore SD, Wondrak GT. (2011) Zinc pyrithione impairs zinc homeostasis and upregulates stress response gene expression in reconstructed human epidermis. Biometals : An International Journal On the Role of Metal Ions in Biology, Biochemistry, and Medicine. 24: 875-90
Cabello CM, Lamore SD, Bair WB, et al. (2011) DCPIP (2,6-dichlorophenolindophenol) as a genotype-directed redox chemotherapeutic targeting NQO1*2 breast carcinoma. Free Radical Research. 45: 276-92
Lamore SD, Qiao S, Horn D, et al. (2010) Proteomic identification of cathepsin B and nucleophosmin as novel UVA-targets in human skin fibroblasts. Photochemistry and Photobiology. 86: 1307-17
Lamore SD, Azimian S, Horn D, et al. (2010) The malondialdehyde-derived fluorophore DHP-lysine is a potent sensitizer of UVA-induced photooxidative stress in human skin cells. Journal of Photochemistry and Photobiology. B, Biology. 101: 251-64
Wondrak GT, Villeneuve NF, Lamore SD, et al. (2010) The cinnamon-derived dietary factor cinnamic aldehyde activates the Nrf2-dependent antioxidant response in human epithelial colon cells. Molecules (Basel, Switzerland). 15: 3338-55
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