Michael E. Pacold
Affiliations: | 2010-2016 | Whitehead Institute (MIT), Cambridge, MA, United States | |
| 2016- | Radiation Oncology | New York University, New York, NY, United States |
Area:
Cancer metabolism, metabolomicsGoogle:
"Michael Pacold"Mean distance: (not calculated yet)
Parents
Sign in to add mentor| Roger L. Williams | grad student | 1999-2003 | MRC-LMB |
| Nathanael Gray | post-doc | 2010- | Dana Farber Cancer Institute |
| David M. Sabatini | post-doc | 2010- | Whitehead Institute (MIT) |
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Publications
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| Wu L, Hollinshead KER, Hao Y, et al. (2020) Niche-Selective Inhibition of Pathogenic Th17 Cells by Targeting Metabolic Redundancy. Cell |
| Pacold ME. (2020) The uninhibited pathway is not worth studying. Nature Chemical Biology. 16: 713-714 |
| Ngo B, Kim E, Osorio-Vasquez V, et al. (2020) Limited Environmental Serine and Glycine Confer Brain Metastasis Sensitivity to PHGDH Inhibition. Cancer Discovery |
| Kory N, Wyant GA, Prakash G, et al. (2018) SFXN1 is a mitochondrial serine transporter required for one-carbon metabolism. Science (New York, N.Y.). 362 |
| Rohde JM, Brimacombe KR, Liu L, et al. (2018) Discovery and optimization of piperazine-1-thiourea-based human phosphoglycerate dehydrogenase inhibitors. Bioorganic & Medicinal Chemistry |
| Lattanzi M, Pacold M, Balar AV. (2018) Association of upregulation of serine and one carbon metabolism genes with shorter recurrence-free and overall survival in urothelial bladder cancer (UBC). Journal of Clinical Oncology. 36: 477-477 |
| Ilic N, Birsoy K, Aguirre AJ, et al. (2017) PIK3CA mutant tumors depend on oxoglutarate dehydrogenase. Proceedings of the National Academy of Sciences of the United States of America |
| Pacold ME, Brimacombe KR, Chan SH, et al. (2016) Corrigendum: A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate. Nature Chemical Biology. 12: 656 |
| Pacold ME, Brimacombe KR, Chan SH, et al. (2016) A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate. Nature Chemical Biology |
| Saxton RA, Knockenhauer KE, Wolfson RL, et al. (2015) Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway. Science (New York, N.Y.) |