Jaebong Jang, Ph D
Affiliations: | Harvard Medical School/Dana-Farber Cancer Institute, Boston, MA, United States |
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Publications
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| Jang H, Park Y, Jang J. (2022) Serum and glucocorticoid-regulated kinase 1: Structure, biological functions, and its inhibitors. Frontiers in Pharmacology. 13: 1036844 |
| Beyett TS, To C, Heppner DE, et al. (2022) Molecular basis for cooperative binding and synergy of ATP-site and allosteric EGFR inhibitors. Nature Communications. 13: 2530 |
| To C, Beyett TS, Jang J, et al. (2022) An allosteric inhibitor against the therapy-resistant mutant forms of EGFR in non-small cell lung cancer. Nature Cancer |
| Gero TW, Heppner DE, Beyett TS, et al. (2022) Quinazolinones as allosteric fourth-generation EGFR inhibitors for the treatment of NSCLC. Bioorganic & Medicinal Chemistry Letters. 128718 |
| Son J, Jang J, Beyett TS, et al. (2022) A novel HER2-selective kinase inhibitor is effective in HER2 mutant and amplified non-small cell lung cancer. Cancer Research |
| Jang J, To C, De Clercq DJH, et al. (2020) Mutant-Selective Allosteric EGFR Degraders are Effective Against a Broad Range of Drug-Resistant Mutations. Angewandte Chemie (International Ed. in English) |
| De Clercq DJH, Heppner DE, To C, et al. (2019) Discovery and Optimization of Dibenzodiazepinones as Allosteric Mutant-Selective EGFR Inhibitors. Acs Medicinal Chemistry Letters. 10: 1549-1553 |
| Lian W, Jang J, Potisopon S, et al. (2019) Correction to Discovery of Immunologically Inspired Small Molecules That Target the Viral Envelope Protein. Acs Infectious Diseases |
| To C, Jang J, Chen T, et al. (2019) Single and dual targeting of mutant EGFR with an allosteric inhibitor. Cancer Discovery |
| Pitts J, Hsia CY, Lian W, et al. (2019) Identification of small molecule inhibitors targeting the Zika virus envelope protein. Antiviral Research |