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Aochiu Chen

Affiliations: 
National Taiwan University, Taipei, Taipei City, Taiwan 
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"Aochiu Chen"
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Tsung-Shing Wang grad student National Taiwan University
Michael D. Burkart grad student 2016- UCSD

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Publications

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Jiang Z, Chen JA, Mohamed OG, et al. (2024) Cryptic Cerulenin Rearrangement in Ketosynthase Covalent Inhibition. Journal of the American Chemical Society
Chen A, Re RN, Davis TD, et al. (2024) Visualizing the Interface of Biotin and Fatty Acid Biosynthesis through SuFEx Probes. Journal of the American Chemical Society
Suo Y, Chen A, La Clair JJ, et al. (2023) Substrate Sequestration and Chain Flipping in Human Mitochondrial Acyl Carrier Protein. Biochemistry
Jiang Z, Chen A, Chen J, et al. (2023) Masked cerulenin enables a dual-site selective protein crosslink. Chemical Science. 14: 10925-10933
Chen A, Mindrebo JT, Davis TD, et al. (2022) Mechanism-based cross-linking probes capture the Escherichia coli ketosynthase FabB in conformationally distinct catalytic states. Acta Crystallographica. Section D, Structural Biology. 78: 1171-1179
Chen A, Jiang Z, Burkart MD. (2022) Enzymology of standalone elongating ketosynthases. Chemical Science. 13: 4225-4238
Mindrebo JT, Chen A, Kim WE, et al. (2021) Structure and mechanistic analyses of the gating mechanism of elongating ketosynthases. Acs Catalysis. 11: 6787-6799
Du D, Katsuyama Y, Horiuchi M, et al. (2020) Structural basis for selectivity in a highly reducing type II polyketide synthase. Nature Chemical Biology
Mindrebo JT, Patel A, Kim WE, et al. (2020) Gating mechanism of elongating β-ketoacyl-ACP synthases. Nature Communications. 11: 1727
Patel A, MIndrebo JT, Kim WE, et al. (2020) A Computational Perspective on the Gating Mechanism of β-Ketoacyl-ACP Synthases Biophysical Journal. 118: 502a
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