Ira J. Smith, Ph.D.

Affiliations: 
2005 University of Florida, Gainesville, Gainesville, FL, United States 
Area:
Animal Physiology Biology, Biochemistry
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Stephen L. Dodd grad student 2005 UF Gainesville
 (Effects of the calpain proteases on the ubiquitin -proteasome system and protein synthesis signaling in rat skeletal muscle.)
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Publications

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Smith IJ, Roberts B, Beharry A, et al. (2016) Janus Kinase Inhibition Prevents Cancer- and Myocardial Infarction-Mediated Diaphragm Muscle Weakness in Mice. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. ajpregu.00550.2016
Tang H, Smith IJ, Hussain SN, et al. (2014) The JAK-STAT pathway is critical in ventilator-induced diaphragm dysfunction. Molecular Medicine (Cambridge, Mass.). 20: 579-89
Li W, Claypool MD, Friera AM, et al. (2014) Noninvasive imaging of in vivo MuRF1 expression during muscle atrophy. Plos One. 9: e94032
Smith IJ, Godinez GL, Singh BK, et al. (2014) Inhibition of Janus kinase signaling during controlled mechanical ventilation prevents ventilation-induced diaphragm dysfunction. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 28: 2790-803
Jenkins Y, Sun TQ, Markovtsov V, et al. (2013) AMPK activation through mitochondrial regulation results in increased substrate oxidation and improved metabolic parameters in models of diabetes. Plos One. 8: e81870
Alamdari N, Toraldo G, Aversa Z, et al. (2012) Loss of muscle strength during sepsis is in part regulated by glucocorticoids and is associated with reduced muscle fiber stiffness. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 303: R1090-9
Smith IJ, Aversa Z, Hasselgren PO, et al. (2011) Calpain activity is increased in skeletal muscle from gastric cancer patients with no or minimal weight loss. Muscle & Nerve. 43: 410-4
Smith IJ, Aversa Z, Alamdari N, et al. (2010) Sepsis downregulates myostatin mRNA levels without altering myostatin protein levels in skeletal muscle. Journal of Cellular Biochemistry. 111: 1059-73
Alamdari N, Smith IJ, Aversa Z, et al. (2010) Sepsis and glucocorticoids upregulate p300 and downregulate HDAC6 expression and activity in skeletal muscle. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 299: R509-20
Smith IJ, Alamdari N, O'Neal P, et al. (2010) Sepsis increases the expression and activity of the transcription factor Forkhead Box O 1 (FOXO1) in skeletal muscle by a glucocorticoid-dependent mechanism. The International Journal of Biochemistry & Cell Biology. 42: 701-11
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