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Ira J. Smith, Ph.D.

Affiliations: 
2005 University of Florida, Gainesville, Gainesville, FL, United States 
Area:
Animal Physiology Biology, Biochemistry
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Stephen L. Dodd grad student 2005 UF Gainesville
 (Effects of the calpain proteases on the ubiquitin -proteasome system and protein synthesis signaling in rat skeletal muscle.)

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Publications

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Smith IJ, Roberts B, Beharry A, et al. (2016) Janus Kinase Inhibition Prevents Cancer- and Myocardial Infarction-Mediated Diaphragm Muscle Weakness in Mice. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. ajpregu.00550.2016
Tang H, Smith IJ, Hussain SN, et al. (2014) The JAK-STAT pathway is critical in ventilator-induced diaphragm dysfunction. Molecular Medicine (Cambridge, Mass.). 20: 579-89
Li W, Claypool MD, Friera AM, et al. (2014) Noninvasive imaging of in vivo MuRF1 expression during muscle atrophy. Plos One. 9: e94032
Smith IJ, Godinez GL, Singh BK, et al. (2014) Inhibition of Janus kinase signaling during controlled mechanical ventilation prevents ventilation-induced diaphragm dysfunction. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 28: 2790-803
Baltgalvis KA, White K, Li W, et al. (2014) Exercise performance and peripheral vascular insufficiency improve with AMPK activation in high-fat diet-fed mice. American Journal of Physiology. Heart and Circulatory Physiology. 306: H1128-45
Jenkins Y, Sun TQ, Markovtsov V, et al. (2013) AMPK activation through mitochondrial regulation results in increased substrate oxidation and improved metabolic parameters in models of diabetes. Plos One. 8: e81870
Alamdari N, Toraldo G, Aversa Z, et al. (2012) Loss of muscle strength during sepsis is in part regulated by glucocorticoids and is associated with reduced muscle fiber stiffness. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 303: R1090-9
Smith IJ, Aversa Z, Hasselgren PO, et al. (2011) Calpain activity is increased in skeletal muscle from gastric cancer patients with no or minimal weight loss. Muscle & Nerve. 43: 410-4
Smith IJ, Aversa Z, Alamdari N, et al. (2010) Sepsis downregulates myostatin mRNA levels without altering myostatin protein levels in skeletal muscle. Journal of Cellular Biochemistry. 111: 1059-73
Menconi MJ, Arany ZP, Alamdari N, et al. (2010) Sepsis and glucocorticoids downregulate the expression of the nuclear cofactor PGC-1beta in skeletal muscle. American Journal of Physiology. Endocrinology and Metabolism. 299: E533-43
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