Thomas A. Spencer
Affiliations: | Chemistry | Dartmouth College, Hanover, NH, United States |
Area:
Organic synthesis, bioorganic chemistry, enzyme mechanismsWebsite:
http://www.dartmouth.edu/~chem/faculty/tas.htmlGoogle:
"Thomas Spencer"Mean distance: 8.17 | S | N | B | C | P |
Parents
Sign in to add mentor| Eugene van Tamelen | grad student | 1960 | UW Madison | |
| (Total synthesis of colchicine) | ||||
Children
Sign in to add trainee| K. Barry Sharpless | research assistant | 1963 | Dartmouth |
| Jeffrey H. Byers | grad student | 1984 | Dartmouth |
| Dansu Li | grad student | 2000 | Dartmouth |
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Publications
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| Gan Y, Spencer TA. (2006) Cholesterol surrogates incorporating a benzophenone as part of the sterol tetracycle. The Journal of Organic Chemistry. 71: 5870-5 |
| Gan Y, Blank DH, Ney JE, et al. (2006) Nonsteroidal benzophenone-containing analogues of cholesterol. The Journal of Organic Chemistry. 71: 5864-9 |
| Wang P, Spencer TA. (2005) Preparation of isotopically labelled benzophenone-containing lipid analogues Journal of Labelled Compounds and Radiopharmaceuticals. 48: 781-788 |
| Nakamura Y, Kotite L, Gan Y, et al. (2004) Molecular mechanism of reverse cholesterol transport: reaction of pre-beta-migrating high-density lipoprotein with plasma lecithin/cholesterol acyltransferase. Biochemistry. 43: 14811-20 |
| Spencer TA, Wang P, Li D, et al. (2004) Benzophenone-containing cholesterol surrogates: synthesis and biological evaluation. Journal of Lipid Research. 45: 1510-8 |
| Wang P, Blank DH, Spencer TA. (2004) Synthesis of benzophenone-containing analogues of phosphatidylcholine. The Journal of Organic Chemistry. 69: 2693-702 |
| Zhang Y, Yu C, Liu J, et al. (2003) Cholesterol is superior to 7-ketocholesterol or 7 alpha-hydroxycholesterol as an allosteric activator for acyl-coenzyme A:cholesterol acyltransferase 1. The Journal of Biological Chemistry. 278: 11642-7 |
| Spencer TA, Li D, Russel JS, et al. (2001) Pharmacophore analysis of the nuclear oxysterol receptor LXRalpha. Journal of Medicinal Chemistry. 44: 886-97 |
| Li D, Spencer TA. (2000) Synthesis of 7alpha-hydroxy derivatives of regulatory oxysterols. Steroids. 65: 529-35 |
| Spencer TA, Li D, Russel JS, et al. (2000) Further studies on the synthesis of 24(S),25-epoxycholesterol. A new, efficient preparation of desmosterol. The Journal of Organic Chemistry. 65: 1919-23 |