Hilal A. Lashuel, Ph. D.
Affiliations: | Molecular and Chemical Biology | École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland |
Area:
NeurodegenerationWebsite:
http://lashuel-lab.epfl.ch/page-18616-en.htmlGoogle:
"Hilal Lashuel"Mean distance: 8.73 | S | N | B | C | P |
Parents
Sign in to add mentorJeffery W. Kelly | grad student | 1994-1999 | Texas A & M | |
(Biophysical studies on the acid denaturation of transthyretin: Understanding the mechanism of fibril formation in human amyloid disease.) |
Children
Sign in to add traineeSalvatore Novello | post-doc | 2019- | EPFL - Brain Mind Institute (Neurotree) |
BETA: Related publications
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Publications
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Yang L, Jasiqi Y, Lashuel H. (2023) Recombinant Full-Length TDP-43 Oligomers Retain Their Ability to Bind RNAs, Are Not Toxic, and Do Not Seed TDP-43 Aggregation in Vitro. Acs Chemical Neuroscience. 15: 193-204 |
Yang L, Jasiqi Y, Zettor A, et al. (2023) Effective Inhibition of TDP-43 Aggregation by Native State Stabilization. Angewandte Chemie (International Ed. in English). 63: e202314587 |
Limorenko G, Tatli M, Kolla R, et al. (2023) Fully co-factor-free ClearTau platform produces seeding-competent Tau fibrils for reconstructing pathological Tau aggregates. Nature Communications. 14: 3939 |
Kumar ST, Nazarov S, Porta S, et al. (2023) Seeding the aggregation of TDP-43 requires post-fibrillization proteolytic cleavage. Nature Neuroscience |
Balana AT, Mahul-Mellier AL, Nguyen BA, et al. (2023) O-GlcNAc modification forces the formation of an α-Synuclein amyloid-strain with notably diminished seeding activity and pathology. Biorxiv : the Preprint Server For Biology |
Altay MF, Liu AKL, Holton JL, et al. (2022) Prominent astrocytic alpha-synuclein pathology with unique post-translational modification signatures unveiled across Lewy body disorders. Acta Neuropathologica Communications. 10: 163 |
Lashuel HA, Mahul-Mellier AL, Novello S, et al. (2022) Revisiting the specificity and ability of phospho-S129 antibodies to capture alpha-synuclein biochemical and pathological diversity. Npj Parkinson's Disease. 8: 136 |
Teixidor J, Novello S, Ortiz D, et al. (2022) On-Demand Nanoliter Sampling Probe for the Collection of Brain Fluid. Analytical Chemistry |
Nazarov S, Chiki A, Boudeffa D, et al. (2022) Structural Basis of Huntingtin Fibril Polymorphism Revealed by Cryogenic Electron Microscopy of Exon 1 HTT Fibrils. Journal of the American Chemical Society. 144: 10723-10735 |
Shillcock JC, Hastings J, Riguet N, et al. (2021) Non-monotonic fibril surface occlusion by GFP tags from coarse-grained molecular simulations. Computational and Structural Biotechnology Journal. 20: 309-321 |