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Joshua R. Sacher, Ph.D.

Affiliations: 
2014- Stanley Center for Psychiatric Research Broad Institute of MIT and Harvard, USA 
Area:
chemistry, synthesis, organic chemistry, medicinal chemistry, neuroscience
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"Joshua Sacher"
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Parents

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Steven M. Weinreb grad student 2005-2012 Penn State
 (Progress toward a total synthesis of the Lycopodium alkaloid lycopladine h.)
Peter Wipf post-doc 2012-2014

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Publications

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Wagner FF, Benajiba L, Campbell AJ, et al. (2018) Exploiting an Asp-Glu "switch" in glycogen synthase kinase 3 to design paralog-selective inhibitors for use in acute myeloid leukemia. Science Translational Medicine. 10
Epperly MW, Sacher JR, Krainz T, et al. (2017) Effectiveness of Analogs of the GS-Nitroxide, JP4-039, as Total Body Irradiation Mitigators. In Vivo (Athens, Greece). 31: 39-43
Krainz T, Gaschler MM, Lim C, et al. (2016) A Mitochondrial-Targeted Nitroxide Is a Potent Inhibitor of Ferroptosis. Acs Central Science. 2: 653-659
Ma J, Lim C, Sacher JR, et al. (2015) Mitochondrial targeted β-lapachone induces mitochondrial dysfunction and catastrophic vacuolization in cancer cells. Bioorganic & Medicinal Chemistry Letters
Chauhan PS, Sacher JR, Weinreb SM. (2015) Synthesis of the tetracyclic skeleton of the Lycopodium alkaloid lycopladine H via a pivotal double hydroformylation/intramolecular reductive amination sequence. Organic Letters. 17: 806-8
Ma J, Lim C, Sacher JR, et al. (2015) Mitochondrial targeted β-lapachone induces mitochondrial dysfunction and catastrophic vacuolization in cancer cells Bioorganic and Medicinal Chemistry Letters
Escobales N, Nuñez RE, Jang S, et al. (2014) Mitochondria-targeted ROS scavenger improves post-ischemic recovery of cardiac function and attenuates mitochondrial abnormalities in aged rats. Journal of Molecular and Cellular Cardiology. 77: 136-46
Skoda EM, Sacher JR, Kazancioglu MZ, et al. (2014) An uncharged oxetanyl sulfoxide as a covalent modifier for improving aqueous solubility. Acs Medicinal Chemistry Letters. 5: 900-4
Sacher JR, Weinreb SM. (2014) DISCUSSION ADDENDUM for: 2‐Trimethylsilylethanesulfonyl Chloride (SES‐Cl) Organic Syntheses. 34-43
Frantz MC, Skoda EM, Sacher JR, et al. (2013) Synthesis of analogs of the radiation mitigator JP4-039 and visualization of BODIPY derivatives in mitochondria. Organic & Biomolecular Chemistry. 11: 4147-53
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