Jian Yu

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2001 Johns Hopkins University, Baltimore, MD 
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"Jian Yu"
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Bert Vogelstein grad student 2001 Johns Hopkins
 (p53-induced genes and apoptosis.)
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Publications

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Chen D, Ermine K, Wang YJ, et al. (2023) PUMA/RIP3 mediates chemotherapy response via necroptosis and local immune activation in colorectal cancer. Molecular Cancer Therapeutics
Tong J, Tan X, Hao S, et al. (2023) Inhibition of multiple CDKs potentiates colon cancer chemotherapy via p73-mediated DR5 induction. Oncogene
Hao S, Tong J, Jha A, et al. (2022) Synthetical lethality of Werner helicase and mismatch repair deficiency is mediated by p53 and PUMA in colon cancer. Proceedings of the National Academy of Sciences of the United States of America. 119: e2211775119
Kuang C, Tong J, Ermine K, et al. (2022) Dual inhibition of BET and HAT/p300 suppresses colorectal cancer via DR5- and p53/PUMA-mediated cell death. Frontiers in Oncology. 12: 1018775
Ruan H, Leibowitz BJ, Peng Y, et al. (2022) Targeting Myc-driven stress vulnerability in mutant KRAS colorectal cancer. Molecular Biomedicine. 3: 10
Tong J, Tan X, Song X, et al. (2022) CDK4/6 inhibition suppresses p73 phosphorylation and activates DR5 to potentiate chemotherapy and immune checkpoint blockade. Cancer Research
Tong J, Tan X, Risnik D, et al. (2021) BET protein degradation triggers DR5-mediated immunogenic cell death to suppress colorectal cancer and potentiate immune checkpoint blockade. Oncogene. 40: 6566-6578
Song X, Shen L, Tong J, et al. (2020) Mcl-1 inhibition overcomes intrinsic and acquired regorafenib resistance in colorectal cancer. Theranostics. 10: 8098-8110
Ruan H, Leibowitz BJ, Zhang L, et al. (2020) Immunogenic cell death in colon cancer prevention and therapy. Molecular Carcinogenesis
Dang Y, Zhang Y, Xu L, et al. (2020) PUMA-mediated epithelial cell apoptosis promotes Helicobacter pylori infection-mediated gastritis. Cell Death & Disease. 11: 139
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