Daniel P. Walker, Ph.D.
Affiliations: | Indiana University, Bloomington, Bloomington, IN, United States |
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Publications
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| Schnute ME, Benoit SE, Buchler IP, et al. (2019) Aminopyrazole Carboxamide Bruton's Tyrosine Kinase Inhibitors. Irreversible to Reversible Covalent Reactive Group Tuning. Acs Medicinal Chemistry Letters. 10: 80-85 |
| Walker DP, Harris GD, Carroll JN, et al. (2019) A new process to prepare 3,6-dichloro-2-hydroxybenzoic acid, the penultimate intermediate in the synthesis of herbicide dicamba Tetrahedron Letters. 60: 1032-1036 |
| Stepan AF, Claffey MM, Reese MR, et al. (2017) Discovery and Characterization of (R)-6-Neopentyl-2-(pyridin-2-ylmethoxy)-6,7-dihydropyrimido[2,1-c][1,4]oxazin-4(9H)-one (PF-06462894), an Alkyne-Lacking Metabotropic Glutamate Receptor 5 Negative Allosteric Modulator Profiled in both Rat and Non-human Primates. Journal of Medicinal Chemistry |
| Blount KF, Megyola C, Plummer M, et al. (2015) Novel Riboswitch-Binding Flavin Analog That Protects Mice against Clostridium difficile Infection without Inhibiting Cecal Flora. Antimicrobial Agents and Chemotherapy. 59: 5736-46 |
| Zhang L, Balan G, Barreiro G, et al. (2014) Discovery and preclinical characterization of 1-methyl-3-(4-methylpyridin-3-yl)-6-(pyridin-2-ylmethoxy)-1H-pyrazolo-[3,4-b]pyrazine (PF470): a highly potent, selective, and efficacious metabotropic glutamate receptor 5 (mGluR5) negative allosteric modulator. Journal of Medicinal Chemistry. 57: 861-77 |
| Daniels JS, Lai Y, South S, et al. (2013) Inhibition of hepatobiliary transporters by a novel kinase inhibitor contributes to hepatotoxicity in beagle dogs. Drug Metabolism Letters. 7: 15-22 |
| Walker DP, Arhancet GB, Lu HF, et al. (2013) Synthesis and biological evaluation of substituted benzoxazoles as inhibitors of mPGES-1: use of a conformation-based hypothesis to facilitate compound design. Bioorganic & Medicinal Chemistry Letters. 23: 1120-6 |
| Arhancet GB, Walker DP, Metz S, et al. (2013) Discovery and SAR of PF-4693627, a potent, selective and orally bioavailable mPGES-1 inhibitor for the potential treatment of inflammation. Bioorganic & Medicinal Chemistry Letters. 23: 1114-9 |
| Walker DP, Rogier DJ. (2013) Preparation of Novel Bridged Bicyclic Thiomorpholines as Potentially Useful Building Blocks in Medicinal Chemistry Synthesis. 45: 2966-2970 |
| Bhattacharya SK, Aspnes GE, Bagley SW, et al. (2012) Identification of novel series of pyrazole and indole-urea based DFG-out PYK2 inhibitors. Bioorganic & Medicinal Chemistry Letters. 22: 7523-9 |