Bruce Mackay
Affiliations: | 1994-1999 | University of Toronto, Toronto, ON, Canada |
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Publications
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| Fournier PA, Arbour M, Cauchon E, et al. (2012) Design and synthesis of potent, isoxazole-containing renin inhibitors. Bioorganic & Medicinal Chemistry Letters. 22: 2670-4 |
| Lévesque JF, Bleasby K, Chefson A, et al. (2011) Impact of passive permeability and gut efflux transport on the oral bioavailability of novel series of piperidine-based renin inhibitors in rodents. Bioorganic & Medicinal Chemistry Letters. 21: 5547-51 |
| Chen A, Cauchon E, Chefson A, et al. (2011) Renin inhibitors for the treatment of hypertension: design and optimization of a novel series of tertiary alcohol-bearing piperidines. Bioorganic & Medicinal Chemistry Letters. 21: 3976-81 |
| Chen A, Campeau LC, Cauchon E, et al. (2011) Renin inhibitors for the treatment of hypertension: design and optimization of a novel series of pyridone-substituted piperidines. Bioorganic & Medicinal Chemistry Letters. 21: 3970-5 |
| Ducharme Y, Blouin M, Brideau C, et al. (2010) The discovery of setileuton, a potent and selective 5-lipoxygenase inhibitor. Acs Medicinal Chemistry Letters. 1: 170-4 |
| Chen A, Dubé D, Dubé L, et al. (2010) Addressing time-dependent CYP 3A4 inhibition observed in a novel series of substituted amino propanamide renin inhibitors, a case study. Bioorganic & Medicinal Chemistry Letters. 20: 5074-9 |
| Chen A, Bayly C, Bezençon O, et al. (2010) Design and optimization of a substituted amino propanamide series of renin inhibitors for the treatment of hypertension. Bioorganic & Medicinal Chemistry Letters. 20: 2204-9 |