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David D. Boehr

Affiliations: 
Chemistry Pennsylvania State University, State College, PA, United States 
Area:
protein dynamics in enzyme function, coordination and regulation
Website:
http://www.chem.psu.edu/directory/ddb12
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"David D. Boehr"
Bio:

http://research.chem.psu.edu/ddbgroup

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Parents

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Gerard D. Wright grad student 2004 McMaster University
 (Molecular investigations into the catalytic mechanisms and inhibition of the aminoglycoside resistance enzymes APH(3')-IIIa and AAC(6')-APH(2").)
Peter E. Wright post-doc 2008 Scripps Institute

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Publications

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D'Amico RN, Boehr DD. (2023) Allostery, engineering and inhibition of tryptophan synthase. Current Opinion in Structural Biology. 82: 102657
O'Rourke KF, D'Amico RN, Sahu D, et al. (2020) Distinct conformational dynamics and allosteric networks in alpha tryptophan synthase during active catalysis. Protein Science : a Publication of the Protein Society
D'Amico RN, Murray AM, Boehr DD. (2020) Driving Protein Conformational Cycles in Physiology and Disease: "Frustrated" Amino Acid Interaction Networks Define Dynamic Energy Landscapes: Amino Acid Interaction Networks Change Progressively Along Alpha Tryptophan Synthase's Catalytic Cycle. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. e2000092
Gorman SD, Winston DS, Sahu D, et al. (2020) Different Solvent and Conformational Entropy Contributions to the Allosteric Activation and Inhibition Mechanisms of Yeast Chorismate Mutase. Biochemistry
Gorman SD, Winston DS, Sahu D, et al. (2020) A Six-State Binding Model Gives Rise to Dynamic Activity and Energy Landscapes in Yeast Chorismate Mutase Biophysical Journal. 118: 519a
Gorman SD, D'Amico RN, Winston DS, et al. (2019) Engineering Allostery into Proteins. Advances in Experimental Medicine and Biology. 1163: 359-384
Boehr AK, Arnold JJ, Oh HS, et al. (2019) 2'-C-Methylated nucleotides terminate virus RNA synthesis by preventing active site closure of the viral RNA-dependent RNA polymerase. The Journal of Biological Chemistry
Gorman SD, Boehr DD. (2019) Energy and Enzyme Activity Landscapes of Yeast Chorismate Mutase at Cellular Concentrations of Allosteric Effectors. Biochemistry. 58: 4058-4069
Shi J, Perryman JM, Yang X, et al. (2019) Rational control of poliovirus RNA-dependent RNA polymerase fidelity by modulating motif D loop conformational dynamics. Biochemistry
O'Rourke KF, Sahu D, Bosken YK, et al. (2019) Coordinated Network Changes across the Catalytic Cycle of Alpha Tryptophan Synthase. Structure (London, England : 1993)
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