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Lorenzo I. Finci, Ph.D.

Affiliations: 
2011 Boston University, Boston, MA, United States 
 2011-2015 Harvard Medical School, Boston, MA, United States 
 2015-2018 Tsinghua National University, Beijing, Beijing Shi, China 
 2018-2019 New York Structural Biology Center 
 2019- Frederick National Laboratory 
Area:
General Biophysics
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Parents

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Karen N. Allen grad student 2011 Boston University
 (The molecular architecture and catalytic mechanisms of BH1999 thioesterase and beta-phosphoglucomutase.)
Jia-huai Wang post-doc 2011-2015 Harvard Medical School
 (Structural and functional studies of neuronal chemotrophic guidance cue netrin-1, its cell surface receptors, and their role in neuronal development and cancer)
Yigong Shi post-doc 2015-2018 Tsinghua University
 (Structural studies of macromolecular machines using single particle cryo- electron microscopy and rational drug design)

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Publications

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Finci LI, Chakrabarti M, Gulten G, et al. (2024) Structural dynamics of RAF1-HSP90-CDC37 and HSP90 complexes reveal asymmetric client interactions and key structural elements. Communications Biology. 7: 260
Finci LI, Zhang X, Huang X, et al. (2018) The cryo-EM structure of the SF3b spliceosome complex bound to a splicing modulator reveals a pre-mRNA substrate competitive mechanism of action. Genes & Development. 32: 309-320
Finci LI, Zhang J, Sun X, et al. (2017) Structure of unliganded membrane-proximal domains FN4-FN5-FN6 of DCC. Protein & Cell
Zhang X, Yan C, Hang J, et al. (2017) An Atomic Structure of the Human Spliceosome. Cell
Finci LI, Krüger N, Sun X, et al. (2014) The crystal structure of netrin-1 in complex with DCC reveals the bifunctionality of netrin-1 as a guidance cue. Neuron. 83: 839-49
Dai J, Finci L, Zhang C, et al. (2009) Analysis of the structural determinants underlying discrimination between substrate and solvent in β-phosphoglucomutase catalysis Biochemistry. 48: 1984-1995
Song F, Zhuang Z, Finci L, et al. (2006) Structure, function, and mechanism of the phenylacetate pathway hot dog-fold thioesterase PaaI. The Journal of Biological Chemistry. 281: 11028-38
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