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Ken J. Hampel

Affiliations: 
University of Vermont, Burlington, VT, United States 
Area:
RNA structure
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"Ken Hampel"
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John M. Burke grad student University of Vermont
Jeremy S. Lee grad student University of Saskatchewan

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Publications

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Hampel KJ, Tinsley MM. (2006) Evidence for preorganization of the glmS ribozyme ligand binding pocket. Biochemistry. 45: 7861-71
Sargueil B, Hampel KJ, Lambert D, et al. (2003) In vitro selection of second site revertants analysis of the hairpin ribozyme active site. The Journal of Biological Chemistry. 278: 52783-91
Hampel KJ, Burke JM. (2003) Solvent protection of the hammerhead ribozyme in the ground state: evidence for a cation-assisted conformational change leading to catalysis. Biochemistry. 42: 4421-9
Pinard R, Hampel KJ, Heckman JE, et al. (2001) Functional involvement of G8 in the hairpin ribozyme cleavage mechanism. The Embo Journal. 20: 6434-42
Hampel KJ, Pinard R, Burke JM. (2001) Catalytic and structural assays for the hairpin ribozyme. Methods in Enzymology. 341: 566-80
Walter NG, Chan PA, Hampel KJ, et al. (2001) A base change in the catalytic core of the hairpin ribozyme perturbs function but not domain docking. Biochemistry. 40: 2580-7
Hampel KJ, Burke JM. (2001) A conformational change in the "loop E-like" motif of the hairpin ribozyme is coincidental with domain docking and is essential for catalysis. Biochemistry. 40: 3723-9
Hampel KJ, Burke JM. (2001) Time-resolved hydroxyl-radical footprinting of RNA using Fe(II)-EDTA. Methods (San Diego, Calif.). 23: 233-9
Pinard R, Lambert D, Heckman JE, et al. (2001) The hairpin ribozyme substrate binding-domain: a highly constrained D-shaped conformation. Journal of Molecular Biology. 307: 51-65
Hampel KJ, Walter NG, Burke JM. (1998) The solvent-protected core of the hairpin ribozyme-substrate complex. Biochemistry. 37: 14672-82
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