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Mamoun Alhamadsheh

Affiliations: 
2011 University of the Pacific, Stockton, CA, United States 
Area:
Chemistry, Biochemistry, Chemical Biology, Molecular Biology, Medicinal Chemistry, Pharmacokinetics
Website:
https://pharmacy.pacific.edu/campus-directory/mamoun-alhamadsheh
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"Mamoun Alhamadsheh"
Bio:

https://books.google.com/books?id=yZMvAQAAIAAJ

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Parents

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Richard A Hudson grad student 2004 The University of Toledo
 (Design, synthesis, and biological evaluation of conformationally restrained epothilone analogues.)
L. M. Viranga Tillekeratne grad student 2004 The University of Toledo
 (Design, synthesis, and biological evaluation of conformationally restrained epothilone analogues.)
Kevin A. Reynolds post-doc
Gerald Crabtree post-doc 2011 Stanford

Children

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Arindom Pal grad student University of the Pacific
Sravan Penchala grad student 2016 University of the Pacific
Mark Miller grad student 2012-2018 University of the Pacific

Collaborators

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Publications

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Amin TU, Emara R, Pal A, et al. (2022) Enhancing the Safety and Efficacy of PSMA-Based Small-Molecule Drug Conjugates by Linker Stabilization and Conjugation to Transthyretin Binding Ligand. Journal of Medicinal Chemistry
Pal A, Albusairi W, Liu F, et al. (2019) Hydrophilic Small Molecules that Harness Transthyretin to Enhance the Safety and Efficacy of Targeted Chemotherapeutic Agents. Molecular Pharmaceutics
Miller M, Pal A, Albusairi W, et al. (2018) Enthalpy-Driven Stabilization of Transthyretin by AG10 Mimics a Naturally Occurring Genetic Variant That Protects from Transthyretin Amyloidosis. Journal of Medicinal Chemistry
Alhamadsheh M, Miller M, Pal A, et al. (2017) P5846AG10, an orally available, novel transthyretin (TTR) stabilizer: integrated preclinical evaluation predicts a highly effective treatment for TTR amyloid cardiomyopathy European Heart Journal. 38
Penchala SC, Miller MR, Pal A, et al. (2015) A biomimetic approach for enhancing the in vivo half-life of peptides. Nature Chemical Biology. 11: 793-8
Penchala SC, Miller MR, Pal A, et al. (2015) A biomimetic approach for enhancing the in vivo half-life of peptides Nature Chemical Biology
Penchala SC, Connelly S, Wang Y, et al. (2013) AG10 inhibits amyloidogenesis and cellular toxicity of the familial amyloid cardiomyopathy-associated V122I transthyretin. Proceedings of the National Academy of Sciences of the United States of America. 110: 9992-7
Papireddy K, Smilkstein M, Kelly JX, et al. (2011) Antimalarial activity of natural and synthetic prodiginines. Journal of Medicinal Chemistry. 54: 5296-306
Whicher JR, Florova G, Sydor PK, et al. (2011) Structure and function of the RedJ protein, a thioesterase from the prodiginine biosynthetic pathway in Streptomyces coelicolor. The Journal of Biological Chemistry. 286: 22558-69
Eustáquio AS, McGlinchey RP, Liu Y, et al. (2009) Biosynthesis of the salinosporamide A polyketide synthase substrate chloroethylmalonyl-coenzyme A from S-adenosyl-L-methionine. Proceedings of the National Academy of Sciences of the United States of America. 106: 12295-300
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