James Dowden, Ph.D
Affiliations: | 1996-1999 | Chemistry | University of Edinburgh, Edinburgh, Scotland, United Kingdom |
| 1999-2005 | Chemistry | University of Bath, Bath, England, United Kingdom | |
| 2005- | Chemistry | University of Nottingham, Nottingham, England, United Kingdom |
Area:
Natural product synthesis, BiochemistryWebsite:
http://www.nottingham.ac.uk/chemistry/people/james.dowdenGoogle:
"James Dowden"Mean distance: 9.15 | S | N | B | C | P |
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Publications
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| Gunnell EA, Al-Noori A, Muhsen U, et al. (2020) Structural and biochemical evaluation of bisubstrate inhibitors of protein arginine N-methyltransferases PRMT1 and CARM1 (PRMT4). The Biochemical Journal |
| Dowden J, Pike RA, Parry RV, et al. (2011) Small molecule inhibitors that discriminate between protein arginine N-methyltransferases PRMT1 and CARM1. Organic & Biomolecular Chemistry. 9: 7814-21 |
| Hong W, Dowden J. (2011) Facile synthesis of N-6 adenosine modified analogue toward S-adenosyl methionine derived probe for protein arginine methyltransferases Chinese Chemical Letters. 22: 1439-1442 |
| Dowden J, Hong W, Parry RV, et al. (2010) Toward the development of potent and selective bisubstrate inhibitors of protein arginine methyltransferases. Bioorganic & Medicinal Chemistry Letters. 20: 2103-5 |
| Stevenson B, Lewis W, Dowden J. (2010) Expedient route to an amine precursor of halichlorine and pinnaic acid from nitrocyclopent-1-ene Synlett. 672-674 |
| Foster SR, Pearce A, Blake AJ, et al. (2007) Novel octavalent cross-linker displays efficient trapping of protein-protein interactions. Chemical Communications (Cambridge, England). 2512-4 |
| Parkesh R, Vasudevan SR, Berry A, et al. (2007) Chemo-enzymatic synthesis and biological evaluation of photolabile nicotinic acid adenine dinuclotide phosphate (NAADP+). Organic & Biomolecular Chemistry. 5: 441-3 |
| Anderson C, Bartlett SJ, Gansner JM, et al. (2007) Chemical genetics suggests a critical role for lysyl oxidase in zebrafish notochord morphogenesis. Molecular Biosystems. 3: 51-9 |
| Dowden J, Berridge G, Moreau C, et al. (2006) Cell-permeant small-molecule modulators of NAADP-mediated Ca2+ release. Chemistry & Biology. 13: 659-65 |
| Dowden J, Brown RS, Moreau C, et al. (2005) Chemical synthesis of the novel Ca2+ messenger NAADP. Nucleosides, Nucleotides & Nucleic Acids. 24: 513-8 |