Shenshen Hu
Affiliations: | University of California, Berkeley, Berkeley, CA, United States |
Area:
Protein chemistryGoogle:
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Publications
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| Zaragoza JPT, Offenbacher AR, Hu S, et al. (2023) Temporal and spatial resolution of distal protein motions that activate hydrogen tunneling in soybean lipoxygenase. Proceedings of the National Academy of Sciences of the United States of America. 120: e2211630120 |
| Hu S, Offenbacher AR, Lu ED, et al. (2019) Comparative kinetic isotope effects on first- and second-order rate constants of soybean lipoxygenase variants uncover a substrate-binding network. The Journal of Biological Chemistry |
| Hu S, Offenbacher AR, Thompson EM, et al. (2019) Biophysical Characterization of a Disabled Double Mutant of Soybean Lipoxygenase: The "Undoing" of Precise Substrate Positioning Relative to Metal Cofactor and an Identified Dynamical Network. Journal of the American Chemical Society |
| Hu S, Soudackov AV, Hammes-Schiffer S, et al. (2017) Enhanced Rigidification within a Double Mutant of Soybean Lipoxygenase Provides Experimental Support for Vibronically Nonadiabatic Proton-Coupled Electron Transfer Models. Acs Catalysis. 7: 3569-3574 |
| Klinman JP, Offenbacher AR, Hu S. (2017) Origins of Enzyme Catalysis: Experimental Findings for C-H Activation, New Models, and Their Relevance to Prevailing Theoretical Constructs. Journal of the American Chemical Society |
| Offenbacher AR, Hu S, Poss EM, et al. (2017) Hydrogen-Deuterium Exchange of Lipoxygenase Uncovers a Relationship between Distal, Solvent Exposed Protein Motions and the Thermal Activation Barrier for Catalytic Proton-Coupled Electron Tunneling. Acs Central Science. 3: 570-579 |
| Hu S, Cattin-Ortolá J, Munos JW, et al. (2016) Hydrostatic Pressure Studies Distinguish Global from Local Protein Motions in C-H Activation by Soybean Lipoxygenase-1. Angewandte Chemie (International Ed. in English) |
| Hu S, Sharma SC, Scouras AD, et al. (2014) Extremely elevated room-temperature kinetic isotope effects quantify the critical role of barrier width in enzymatic C-H activation. Journal of the American Chemical Society. 136: 8157-60 |
| Lv J, Zhang L, Hu S, et al. (2012) Asymmetric binary-acid catalysis with InBr3 in the inverse-electron-demanding hetero-Diels-Alder reaction of mono- and bis-substituted cyclopentadienes: remote fluoro-effect on stereocontrol. Chemistry (Weinheim An Der Bergstrasse, Germany). 18: 799-803 |
| Hu S, Zhang L, Li J, et al. (2011) Chiral primary amine catalyzed asymmetric direct cross-aldol reaction of acetaldehyde European Journal of Organic Chemistry. 3347-3352 |