Ujjal Sarkar, Ph.D.
Affiliations: | 2009 | University of Missouri - Columbia, Columbia, MO, United States |
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Parents
Sign in to add mentor| Kent S. Gates | grad student | 2009 | University of Missouri - Columbia | |
| (Metabolically activated heterocyclic N-oxide compounds for killing and visualizing hypoxic cancer cells.) | ||||
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Publications
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| Shen X, Laber CH, Sarkar U, et al. (2018) Exploiting the inherent photophysical properties of the major tirapazamine metabolite in the development of profluorescent substrates for enzymes that catalyze the bioreductive activation of hypoxia-selective anticancer prodrugs. The Journal of Organic Chemistry |
| Sarkar U, Hillebrand R, Johnson KM, et al. (2017) Application of Suzuki-Miyaura and Buchwald-Hartwig Cross-coupling Reactions to the Preparation of Substituted 1,2,4-Benzotriazine 1-Oxides Related to the Antitumor Agent Tirapazamine. Journal of Heterocyclic Chemistry. 54: 155-160 |
| Rajapakse A, Linder C, Morrison RD, et al. (2013) Enzymatic conversion of 6-nitroquinoline to the fluorophore 6-aminoquinoline selectively under hypoxic conditions. Chemical Research in Toxicology. 26: 555-63 |
| Chowdhury G, Sarkar U, Pullen S, et al. (2012) DNA strand cleavage by the phenazine di-N-oxide natural product myxin under both aerobic and anaerobic conditions. Chemical Research in Toxicology. 25: 197-206 |
| Sarkar U, Glaser R, Parsons ZD, et al. (2010) Synthesis, Crystal Structure, and Rotational Energy Profile of 3-Cyclopropyl-1,2,4-benzotriazine 1,4-Di-N-oxide. Journal of Chemical Crystallography. 40: 624-629 |
| Rajapakse A, Sarkar U, Linder C, et al. (2010) Abstract 4558: 6-Nitroquinoline as a metabolically-activated probe for direct fluorescence detection of hypoxia Cancer Research. 70: 4558-4558 |
| Junnotula V, Sarkar U, Sinha S, et al. (2009) Initiation of DNA strand cleavage by 1,2,4-benzotriazine 1,4-dioxide antitumor agents: mechanistic insight from studies of 3-methyl-1,2,4-benzotriazine 1,4-dioxide. Journal of the American Chemical Society. 131: 1015-24 |
| Glaser R, Sui Y, Sarkar U, et al. (2008) Electronic structures and spin topologies of gamma-picoliniumyl radicals. A study of the homolysis of N-methyl-gamma-picolinium and of benzo-, dibenzo-, and naphthoannulated analogs. The Journal of Physical Chemistry. A. 112: 4800-14 |
| Sui Y, Glaser R, Sarkar U, et al. (2007) Stabilities and Spin Distributions of Benzannulated Benzyl Radicals. Journal of Chemical Theory and Computation. 3: 1091-9 |
| Solano B, Junnotula V, Marín A, et al. (2007) Synthesis and biological evaluation of new 2-arylcarbonyl-3-trifluoromethylquinoxaline 1,4-di-N-oxide derivatives and their reduced analogues. Journal of Medicinal Chemistry. 50: 5485-92 |