John C. Widen
Affiliations: | 2011-2017 | Medicinal Chemistry | University of Minnesota, Twin Cities, Minneapolis, MN |
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Sign in to add mentor| Daniel A. Harki | grad student | 2011-2017 | UMN | |
| (Design and Synthesis of Natural Product-Inspired, Cysteine Reactive Probes toward Inhibition of Transcription Factors and Target Identification Studies) | ||||
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Publications
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| Ghani LA, Yusenko MV, Frank D, et al. (2022) A synthetic covalent ligand of the C/EBPβ transactivation domain inhibits acute myeloid leukemia cells. Cancer Letters |
| Jackson PA, Schares HAM, Jones KFM, et al. (2020) Synthesis of Guaianolide Analogues with a Tunable α-Methylene-γ-lactam Electrophile and Correlating Bioactivity with Thiol Reactivity. Journal of Medicinal Chemistry |
| Divakaran A, Talluri SK, Ayoub AM, et al. (2018) Molecular Basis for the N-Terminal Bromodomain and Extra Terminal (BET) Family Selectivity of a Dual Kinase-Bromodomain Inhibitor. Journal of Medicinal Chemistry |
| Naumann JA, Widen JC, Jonart LA, et al. (2018) SN-38 conjugated gold nanoparticles activated by Ewing sarcoma specific mRNAs exhibit in vitro and in vivo efficacy. Bioconjugate Chemistry |
| Widen JC, Kempema AM, Baur JW, et al. (2018) Helenalin Analogues Targeting NF-κB p65: Thiol Reactivity and Cellular Potency Studies of Varied Electrophiles. Chemmedchem |
| Widen JC, Kempema AM, Baur JW, et al. (2018) Front Cover: Helenalin Analogues Targeting NF-κB p65: Thiol Reactivity and Cellular Potency Studies of Varied Electrophiles (ChemMedChem 4/2018) Chemmedchem. 13: 288-288 |
| Widen JC, Kempema AM, Villalta PW, et al. (2017) Targeting NF-κB p65 with a Helenalin Inspired Bis-electrophile. Acs Chemical Biology. 12: 102-113 |
| Jackson PA, Widen JC, Harki DA, et al. (2016) Covalent Modifiers: A Chemical Perspective on the Reactivity of α,β-Unsaturated Carbonyls with Thiols via Hetero-Michael Addition Reactions. Journal of Medicinal Chemistry |
| Wells SM, Widen JC, Harki DA, et al. (2016) Alkyne Ligation Handles: Propargylation of Hydroxyl, Sulfhydryl, Amino, and Carboxyl Groups via the Nicholas Reaction. Organic Letters |
| Kempema AM, Widen JC, Hexum JK, et al. (2015) Synthesis and antileukemic activities of C1-C10-modified parthenolide analogues. Bioorganic & Medicinal Chemistry. 23: 4737-45 |