Isaac T Schiefer
Affiliations: | University of Toledo, Toledo, OH, United States |
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CNS drug discoveryGoogle:
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| Weerawarna PM, Schiefer IT, Soares P, et al. (2023) Target Identification of a Class of Pyrazolone Protein Aggregation Inhibitor Therapeutics for Amyotrophic Lateral Sclerosis. Acs Central Science. 10: 87-103 |
| Tackie-Yarboi E, Wisner A, Horton A, et al. (2020) Combining Neurobehavioral Analysis and In Vivo Photoaffinity Labeling to Understand Protein Targets of Methamphetamine in Casper Zebrafish. Acs Chemical Neuroscience |
| Horton A, Schiefer IT. (2019) Pharmacokinetics and pharmacodynamics of nitric oxide mimetic agents. Nitric Oxide : Biology and Chemistry |
| Horton A, Nash K, Tackie-Yarboi E, et al. (2018) Furoxans (oxadiazole-4N-oxides) with Attenuated Reactivity are Neuroprotective, Cross the Blood Brain Barrier, and Improve Passive Avoidance Memory. Journal of Medicinal Chemistry |
| Nash KM, Schiefer IT, Shah ZA. (2017) Development of a reactive oxygen species-sensitive nitric oxide synthase inhibitor for the treatment of ischemic stroke. Free Radical Biology & Medicine. 115: 395-404 |
| Fà M, Zhang H, Staniszewski A, et al. (2015) Novel Selective Calpain 1 Inhibitors as Potential Therapeutics in Alzheimer's Disease. Journal of Alzheimer's Disease : Jad |
| Trippier PC, Zhao KT, Fox SG, et al. (2014) Proteasome activation is a mechanism for pyrazolone small molecules displaying therapeutic potential in amyotrophic lateral sclerosis. Acs Chemical Neuroscience. 5: 823-9 |
| Schiefer IT, Tapadar S, Litosh V, et al. (2013) Design, synthesis, and optimization of novel epoxide incorporating peptidomimetics as selective calpain inhibitors. Journal of Medicinal Chemistry. 56: 6054-68 |
| Siklos MI, Gandhi RP, Xiong R, et al. (2013) Discovery of neuroprotective soluble guanylate cyclase modulators (GCMs) aciting via NO/GC/cGMP/CREB pathway Bmc Pharmacology and Toxicology. 14 |
| Schiefer IT, VandeVrede L, Fa' M, et al. (2012) Furoxans (1,2,5-oxadiazole-N-oxides) as novel NO mimetic neuroprotective and procognitive agents. Journal of Medicinal Chemistry. 55: 3076-87 |