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Daniel Afosah

Affiliations: 
2012-2021 Virginia Commonwealth University, Richmond, VA, United States 
 2021- Washington and Lee University, Lexington, VA, United States 
Area:
Synthetic organic chemistry, computer-aided drug design, and biochemical techniques
Website:
https://my.wlu.edu/directory/profile?ID=x28004
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"Daniel Afosah"
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Umesh R. Desai grad student 2012-2017 VCU
 (PhD: Study of Interactions of Glycosaminoglycans (GAGs) and GAG Mimetics with their Protein Targets. Also post-doc from 2017-2021)

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Publications

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Al-Horani RA, Abdelfadiel EI, Afosah DK, et al. (2019) A Synthetic Heparin Mimetic That Allosterically Inhibits Factor XIa and Reduces Thrombosis In Vivo Without Enhanced Risk of Bleeding. Journal of Thrombosis and Haemostasis : Jth
Morla S, Sankaranarayanan NV, Afosah DK, et al. (2019) On the Process of Discovering Leads that Target the Heparin-Binding Site of Neutrophil Elastase in the Sputum of Cystic Fibrosis Patients. Journal of Medicinal Chemistry
Patel NR, Patel DV, Kanhed AM, et al. (2019) 2-Aminobenzamide-Based Factor Xa Inhibitors with Novel Mono- and Bi-Aryls as S4 Binding Elements Chemistryselect. 4: 802-809
Afosah DK, Al-Horani RA. (2018) Sulfated Non-Saccharide Glycosaminoglycan Mimetics as Novel Drug Discovery Platform for Various Pathologies. Current Medicinal Chemistry
Gangji RN, Sankaranarayanan NV, Elste J, et al. (2018) Inhibition of Herpes Simplex Virus-1 Entry into Human Cells by Nonsaccharide Glycosaminoglycan Mimetics. Acs Medicinal Chemistry Letters. 9: 797-802
Kummarapurugu AB, Afosah DK, Sankaranarayanan NV, et al. (2018) Molecular principles for heparin oligosaccharide-based inhibition of neutrophil elastase in cystic fibrosis. The Journal of Biological Chemistry
Al-Horani RA, Afosah DK. (2018) Recent advances in the discovery and development of factor XI/XIa inhibitors. Medicinal Research Reviews. 38: 1974-2023
Afosah DK, Verespy S, Al-Horani RA, et al. (2018) A small group of sulfated benzofurans induces steady-state submaximal inhibition of thrombin. Bioorganic & Medicinal Chemistry Letters
Afosah DK, Al-Horani RA, Sankaranarayanan NV, et al. (2016) Potent, Selective, Allosteric Inhibition of Human Plasmin by Sulfated Non-Saccharide Glycosaminoglycan Mimetics. Journal of Medicinal Chemistry
Zheng S, Kummarapurugu AB, Afosah DK, et al. (2016) 2-O, 3-O Desulfated Heparin Blocks HMGB1 Release by Inhibition of p300 Acetyltransferase Activity. American Journal of Respiratory Cell and Molecular Biology
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