Lee Zou
Affiliations: | Cold Spring Harbor Laboratory, Cold Spring Harbor, NY | ||
| MGH | Harvard Medical School, Boston, MA, United States |
Website:
http://www.massgeneral.org/cancerresearch/research/researchlab.aspx?id=1198Google:
"Lee Zou"Bio:
http://www.ibp.cas.cn/xshd/2010xshd/201005/W020100510302772189113.pdf
Mean distance: (not calculated yet)
Parents
Sign in to add mentor| Bruce W. Stillman | grad student | 1999 | SUNY Stony Brook | |
| (Connecting the initiation of DNA replication to the cell cycle) | ||||
| Stephen J. Elledge | post-doc | 2000-2003 | Baylor College of Medicine | |
Children
Sign in to add trainee| Sneha Saxena | post-doc | MGH Harvard Medical School | |
| Tribhuwan Yadav | post-doc |
Collaborators
Sign in to add collaborator| Michael S. Lawrence | collaborator | 2016- | Massachusetts General Hospital Cancer Center (Cell Biology Tree) |
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Publications
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| Wang Y, Gao B, Zhang L, et al. (2024) Meiotic protein SYCP2 confers resistance to DNA-damaging agents through R-loop-mediated DNA repair. Nature Communications. 15: 1568 |
| Kawale AS, Ran X, Patel PS, et al. (2024) APOBEC3A induces DNA gaps through PRIMPOL and confers gap-associated therapeutic vulnerability. Science Advances. 10: eadk2771 |
| Wang M, Ran X, Leung W, et al. (2023) ATR inhibition induces synthetic lethality in mismatch repair-deficient cells and augments immunotherapy. Genes & Development |
| Joo YK, Black EM, Trier I, et al. (2023) ATR promotes clearance of damaged DNA and damaged cells by rupturing micronuclei. Molecular Cell. 83: 3642-3658.e4 |
| Yang H, Lachtara EM, Ran X, et al. (2023) The RNA m5C modification in R-loops as an off switch of Alt-NHEJ. Nature Communications. 14: 6114 |
| Igarashi T, Mazevet M, Yasuhara T, et al. (2023) An ATR-PrimPol pathway confers tolerance to oncogenic KRAS-induced and heterochromatin-associated replication stress. Nature Communications. 14: 4991 |
| Leung W, Simoneau A, Saxena S, et al. (2023) ATR protects ongoing and newly assembled DNA replication forks through distinct mechanisms. Cell Reports. 42: 112792 |
| Zou L. (2023) Heterochromatin-Dependent Replication Stress: A Lesson from IDH1/2 Mutants. Cancer Research. 83: 2987-2989 |
| Isozaki H, Sakhtemani R, Abbasi A, et al. (2023) Therapy-induced APOBEC3A drives evolution of persistent cancer cells. Nature |
| Bamezai S, Pulikkottil AJ, Yadav T, et al. (2023) A non-canonical enzymatic function of PIWIL4 maintains genomic integrity and leukemic growth in AML. Blood |