Jacob I. Contreras
Affiliations: | 2012-2017 | University of Nebraska Medical Center, Omaha, NE, United States |
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Sign in to add mentor| Amarnath (Amar) Natarajan | grad student | 2012-2017 | University of Nebraska Medical Center |
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Publications
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| Sagar S, Singh S, Mallareddy JR, et al. (2021) Structure activity relationship (SAR) study identifies a quinoxaline urea analog that modulates IKKβ phosphorylation for pancreatic cancer therapy. European Journal of Medicinal Chemistry. 222: 113579 |
| Robb CM, Kour S, Contreras JI, et al. (2020) Correction: Characterization of CDK(5) inhibitor, 20-223 (aka CP668863) for colorectal cancer therapy. Oncotarget. 11: 2462-2463 |
| Rana S, Kour S, Sonawane YA, et al. (2020) Symbiotic Prodrugs (SymProDs) Dual Targeting of NFkappaB and CDK. Chemical Biology & Drug Design |
| Kour S, Rana S, Contreras JI, et al. (2019) CDK5 Inhibitor Downregulates Mcl-1 and Sensitizes Pancreatic Cancer Cell Lines to Navitoclax. Molecular Pharmacology. 96: 419-429 |
| Contreras JI, Robb CM, King HM, et al. (2018) Chemical Genetic Screens Identify Kinase Inhibitor Combinations that Target Anti-Apoptotic Proteins for Cancer Therapy. Acs Chemical Biology |
| Robb CM, Kour S, Contreras JI, et al. (2018) Characterization of CDK(5) inhibitor, 20-223 (aka CP668863) for colorectal cancer therapy. Oncotarget. 9: 5216-5232 |
| Robb CM, Contreras JI, Kour S, et al. (2017) Chemically induced degradation of CDK9 by a proteolysis targeting chimera (PROTAC). Chemical Communications (Cambridge, England) |
| Yefidoff-Freedman R, Fan J, Yan L, et al. (2017) Development of 1-((1,4-trans)-4-aryloxycyclohexyl)-3-arylurea Activators of the Heme Regulated Inhibitor as Selective Activators of Eucaryotic Translation Initiation Factor 2 Alpha (eIF2α) Phosphorylation Arm of the Integrated Endoplasmic Reticulum Stress Response. Journal of Medicinal Chemistry |
| Arnst JL, Hein AL, Taylor MA, et al. (2017) Discovery and characterization of small molecule Rac1 inhibitors. Oncotarget |
| Sonawane YA, Taylor MA, Napoleon JV, et al. (2016) Cyclin dependent kinase 9 inhibitors for cancer therapy. Journal of Medicinal Chemistry |