Rodney Lyle Johnson
Affiliations: | 1979- | Medicinal Chemistry | University of Minnesota, Twin Cities, Minneapolis, MN |
Area:
Peptidomimetics, dopamine receptors, allosteric modulatorsWebsite:
https://www.pharmacy.umn.edu/bio/cop-experts/rodney-johnsonGoogle:
"Rodney Lyle Johnson"Mean distance: (not calculated yet)
Parents
Sign in to add mentor| Edward Ervin Smissman | grad student | 1974 | University of Kansas | |
| Gary L. Grunewald | grad student | 1976 | University of Kansas | |
| (A study of the structural requirements for dopa potentiation by the hypothalamic hormone L-prolyl-L-leucylglycinamide.) | ||||
Children
Sign in to add trainee| Sarika V. Prabhu | grad student | 2002 | UMN |
| Abigail L. Fisher | grad student | 2005 | UMN |
| Bhooma Raghavan | grad student | 2006 | UMN |
| Ashish P. Vartak | grad student | 2006 | UMN |
| Cory Kending | grad student | 2008 | UMN |
| Swapna Bhagwanth | grad student | 2009 | UMN |
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Publications
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| Basu D, Tian Y, Hui P, et al. (2015) Change in expression of vesicular protein synapsin II by chronic treatment with D2 allosteric modulator PAOPA. Peptides. 66: 58-62 |
| Basu D, Tian Y, Bhandari J, et al. (2013) Effects of the dopamine D2 allosteric modulator, PAOPA, on the expression of GRK2, arrestin-3, ERK1/2, and on receptor internalization. Plos One. 8: e70736 |
| Tan ML, Basu D, Kwiecien JM, et al. (2013) Preclinical pharmacokinetic and toxicological evaluation of MIF-1 peptidomimetic, PAOPA: examining the pharmacology of a selective dopamine D2 receptor allosteric modulator for the treatment of schizophrenia. Peptides. 42: 89-96 |
| Bhagwanth S, Mishra RK, Johnson RL. (2013) Development of peptidomimetic ligands of Pro-Leu-Gly-NH(2) as allosteric modulators of the dopamine D(2) receptor. Beilstein Journal of Organic Chemistry. 9: 204-14 |
| Beyaert MG, Daya RP, Dyck BA, et al. (2013) PAOPA, a potent dopamine D2 receptor allosteric modulator, prevents and reverses behavioral and biochemical abnormalities in an amphetamine-sensitized preclinical animal model of schizophrenia. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. 23: 253-62 |
| Bhagwanth S, Mishra S, Daya R, et al. (2012) Transformation of Pro-Leu-Gly-NH2 peptidomimetic positive allosteric modulators of the dopamine D2 receptor into negative modulators. Acs Chemical Neuroscience. 3: 274-84 |
| Dyck B, Guest K, Sookram C, et al. (2011) PAOPA, a potent analogue of Pro-Leu-glycinamide and allosteric modulator of the dopamine D2 receptor, prevents NMDA receptor antagonist (MK-801)-induced deficits in social interaction in the rat: implications for the treatment of negative symptoms in schizophrenia. Schizophrenia Research. 125: 88-92 |
| Mann A, Verma V, Basu D, et al. (2010) Specific binding of photoaffinity-labeling peptidomimetics of Pro-Leu-Gly-NH2 to the dopamine D2L receptor: evidence for the allosteric modulation of the dopamine receptor. European Journal of Pharmacology. 641: 96-101 |
| Wood RL, Young-Dixon BJ, Roy A, et al. (2010) Evaluation of Density Functionals, SCC-DFTB, Neglect of Diatomic Differential Overlap (NDDO) Models and Molecular Mechanics Methods for Prolyl-Leucyl-Glycinamide (PLG) and Structural Derivatives. Theochem. 944: 76-82 |
| Raghavan B, Skoblenick KJ, Bhagwanth S, et al. (2009) Allosteric modulation of the dopamine D2 receptor by Pro-Leu-Gly-NH2 peptidomimetics constrained in either a polyproline II helix or a type II beta-turn conformation. Journal of Medicinal Chemistry. 52: 2043-51 |