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Feng Guo, Ph.D.

Affiliations: 
2004- Chemistry University of California, Los Angeles, Los Angeles, CA 
Area:
Structure and Function of Non-coding RNAs
Website:
http://www.biolchem.ucla.edu/people/faculty/feng-guo
Google:
"Feng Guo"
Bio:

Dr. Guo is a structural biologist and biochemist who joined the UCLA School of Medicine faculty in July 2004. He earned his B.S. in Biophysics at the Nankai University and M.S. in Physical Chemistry at the Peking University, both in China. Dr. Guo received his Ph.D. in Biochemistry and Biophysics at the University of Pennsylvania in 2000. In graduate school, he studied the Cre-loxP site-specific DNA recombination using X-ray crystallography. He was a postdoctoral fellow with Dr. Thomas Cech at the University of Colorado at Boulder, where he worked on the thermostability and crystal structure of large ribozymes.

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Parents

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Gregory D. Van Duyne grad student 2000 Penn
 (Structural studies on the mechanism of Cre-loxP site -specific recombination.)
Thomas R. Cech post-doc CU Boulder

Children

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Rachel J. Senturia grad student 2012 UCLA
Ian Barr grad student 2007-2012 UCLA

Collaborators

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Publications

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Lei M, Du X, Li X, et al. (2022) LINC00665 regulates hepatocellular carcinoma by modulating mRNA via the m6A enzyme. Open Life Sciences. 17: 71-80
Guo F, Fu Q, Wang Y, et al. (2019) Long non-coding RNA NR2F1-AS1 promoted proliferation and migration yet suppressed apoptosis of thyroid cancer cells through regulating miRNA-338-3p/CCND1 axis. Journal of Cellular and Molecular Medicine
Li J, Yu Z, Xu J, et al. (2018) The Effect of Ca, Lobe-Specificity, and CaMKII on CaM Binding to Na1.1. International Journal of Molecular Sciences. 19
Shoffner GM, Wang R, Podell E, et al. (2018) In Crystallo Selection to Establish New RNA Crystal Contacts. Structure (London, England : 1993)
Lal S, Comer JM, Konduri PC, et al. (2017) Heme promotes transcriptional and demethylase activities of Gis1, a member of the histone demethylase JMJD2/KDM4 family. Nucleic Acids Research
Hines JP, Smith AT, Jacob JP, et al. (2016) CO and NO bind to Fe(II) DiGeorge critical region 8 heme but do not restore primary microRNA processing activity. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry
Barr I, Guo F. (2015) Pyridine Hemochromagen Assay for Determining the Concentration of Heme in Purified Protein Solutions. Bio-Protocol. 5
Barr I, Weitz SH, Atkin T, et al. (2015) Cobalt(III) Protoporphyrin Activates the DGCR8 Protein and Can Compensate microRNA Processing Deficiency. Chemistry & Biology. 22: 793-802
Quick-Cleveland J, Jacob JP, Weitz SH, et al. (2014) The DGCR8 RNA-binding heme domain recognizes primary microRNAs by clamping the hairpin. Cell Reports. 7: 1994-2005
Zhang W, Zang J, Jing X, et al. (2014) Identification of candidate miRNA biomarkers from miRNA regulatory network with application to prostate cancer. Journal of Translational Medicine. 12: 66
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