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Piero Benedetti, PhD

Affiliations: 
Biology University of Padova, Padova, Veneto, Italy 
Area:
DNA Topology, Topoisomerases, electron microscopy
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"Piero Benedetti"
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Parents

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Glauco P Tocchini-Valentini grad student 1973-1984 National Research Council
 (Research associate)
James C. Wang research scientist 1988-1991

Children

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Paola Fiorani grad student National Research Council
Luca Pattarello grad student Head of R&D - Quality - Regulatory Italchimica
Carmen Losasso post-doc Istituto Zooprofilattico delle Venezie
Antonino Schepis research scientist UCSF

Collaborators

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Publications

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Mičetić I, Losasso C, Muro PD, et al. (2010) Solution structures of 2×6-meric and 4×6-meric hemocyanins of crustaceans Carcinus aestuarii, Squilla mantis and Upogebia pusilla. Journal of Structural Biology. 171: 1-10
Losasso C, Cretaio E, Fiorani P, et al. (2008) A single mutation in the 729 residue modulates human DNA topoisomerase IB DNA binding and drug resistance. Nucleic Acids Research. 36: 5635-44
Chillemi G, D'Annessa I, Fiorani P, et al. (2008) Thr729 in human topoisomerase I modulates anti-cancer drug resistance by altering protein domain communications as suggested by molecular dynamics simulations. Nucleic Acids Research. 36: 5645-51
Palle K, Pattarello L, van der Merwe M, et al. (2008) Disulfide cross-links reveal conserved features of DNA topoisomerase I architecture and a role for the N terminus in clamp closure. The Journal of Biological Chemistry. 283: 27767-75
PALLE K, PATTARELLO L, VAN DER MERWE M, et al. (2008) Disulfide cross-links reveal conserved features of DNA topoisomerase I architecture and a role for the N terminus in clamp closure. J Biol Chem. 27767-75
LOSASSO C, CRETAIO E, FIORANI P, et al. (2008) A single mutation in the 729 residue modulates human DNA topoisomerase IB DNA binding and drug resistance.. Nucleic Acids Res.. 5635-44.
Cretaio E, Pattarello L, Fontebasso Y, et al. (2007) Human DNA topoisomerase IB: structure and functions. The Italian Journal of Biochemistry. 56: 91-102
Corbett KD, Benedetti P, Berger JM. (2007) Holoenzyme assembly and ATP-mediated conformational dynamics of topoisomerase VI. Nature Structural & Molecular Biology. 14: 611-9
Losasso C, Cretaio E, Palle K, et al. (2007) Alterations in linker flexibility suppress DNA topoisomerase I mutant-induced cell lethality. The Journal of Biological Chemistry. 282: 9855-64
LOSASSO C, CRETAIO E, PALLE K, et al. (2007) ALTERATIONS IN LINKER FLEXIBILITY SUPPRESS DNA TOPOISOMERASE I MUTANT-INDUCED CELL LETHALITY. J Biol Chem.. 9855-64.
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