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James R. Horn

Affiliations: 
2006- Chemistry and Biochemistry Northern Illinois University, DeKalb, IL, United States 
Area:
Protein Interactions; Protein Engineering
Website:
http://hornlab.niu.edu
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Parents

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Kenneth P. Murphy grad student 2002 University of Iowa
Brian K. Shoichet post-doc 2002-2003 Northwestern
Anthony A. Kossiakoff post-doc 2006 Chicago

Children

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Sean W. Fanning grad student 2012 Northern Illinois University
Megan L. Murtaugh grad student 2013 Northern Illinois University

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Publications

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Smith CA, Sonneson GJ, Hoey RJ, et al. (2023) Molecular recognition requires dimerization of a VHH antibody. Mabs. 15: 2215363
Laughlin TM, Horn JR. (2022) Engineering pH-Sensitive Single-Domain Antibodies. Methods in Molecular Biology (Clifton, N.J.). 2446: 269-298
Blain JM, Grote DL, Watkins SM, et al. (2021) Structural and biophysical characterization of the Burkholderia pseudomallei IspF inhibitor L-tryptophan hydroxamate. Bioorganic & Medicinal Chemistry Letters. 48: 128273
Hoey RJ, Eom H, Horn JR. (2019) Structure and development of single domain antibodies as modules for therapeutics and diagnostics. Experimental Biology and Medicine (Maywood, N.J.). 1535370219881129
Watkins SM, Ghose D, Blain JM, et al. (2019) Antibacterial activity of 2-amino-4-hydroxypyrimidine-5-carboxylates and binding to Burkholderia pseudomallei 2-C-methyl-d-erythritol-2,4-cyclodiphosphate synthase. Bioorganic & Medicinal Chemistry Letters. 126660
Kossiakoff AA, Mukherjee S, Horn JR. (2018) Reply to Kang and Brooks: Comment on the calculations in protein thermodynamics. The Journal of Biological Chemistry. 293: 5063
Helgren TR, Seven ES, Chen C, et al. (2018) The identification of inhibitory compounds of Rickettsia prowazekii methionine aminopeptidase for antibacterial applications. Bioorganic & Medicinal Chemistry Letters
Mukherjee S, Griffin DH, Horn JR, et al. (2018) Engineered synthetic antibodies as probes to quantify the energetic contributions of ligand binding to conformational changes in proteins. The Journal of Biological Chemistry
Davenport KR, Smith CA, Hofstetter H, et al. (2016) Site-directed immobilization of a genetically engineered anti-methotrexate antibody via an enzymatically introduced biotin label significantly increases the binding capacity of immunoaffinity columns. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
Horn JR, Murtaugh ML, Fanning SW, et al. (2015) Remodeling Protein Interfaces to Regulate Recognition Biophysical Journal. 108: 627a-628a
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