J. P. Kirwan, Ph.D.

Affiliations: 
2012 University of Colorado Anschutz Medical Campus, Denver, Aurora, CO 
Area:
Biochemistry, Medical Biophysics
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"J. Kirwan"
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Robert Stanley Hodges grad student 2012 University of Colorado, Denver
 (A stability control region in tropomyosin transmits long-range effects to achieve optimum stability.)
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Publications

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Kirwan JP, Hodges RS. (2014) Transmission of stability information through the N-domain of tropomyosin is interrupted by a stabilizing mutation (A109L) in the hydrophobic core of the stability control region (residues 97-118). The Journal of Biological Chemistry. 289: 4356-66
Kirwan JP, Hodges RS. (2010) Critical interactions in the stability control region of tropomyosin. Journal of Structural Biology. 170: 294-306
Hodges RS, Mills J, McReynolds S, et al. (2009) Identification of a unique "stability control region" that controls protein stability of tropomyosin: A two-stranded alpha-helical coiled-coil. Journal of Molecular Biology. 392: 747-62
Kirwan JP, Kwok SC, McReynolds S, et al. (2009) Unique role of clusters of electrostatic attractions in controlling the stability of two-stranded alpha-helical coiled-coils. Advances in Experimental Medicine and Biology. 611: 77-8
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