David J. Kast, Ph.D.
Affiliations: | 2010 | Biochemistry, Molecular Bio, and Biophysics | University of Minnesota, Twin Cities, Minneapolis, MN |
| 2010-2017 | Physiology | University of Pennsylvania Perelman School of Medicine | |
| 2017- | Cell Biology and Physiology | Washington University School of Medicine, Saint Louis |
Area:
Biophysics, Biomechanics, BiochemistryGoogle:
"David Kast"Mean distance: (not calculated yet)
Parents
Sign in to add mentor| David Dale Thomas | grad student | 2010 | UMN | |
| (Phosphorylation-induced structural changes in smooth muscle myosin.) | ||||
Children
Sign in to add trainee| Victoria A. Ismail | grad student | 2018- | Washington University School of Medicine in St. Louis (Neurotree) |
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Publications
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| Kast DJ, Dominguez R. (2019) IRSp53 coordinates AMPK and 14-3-3 signaling to regulate filopodia dynamics and directed cell migration. Molecular Biology of the Cell. mbcE18090600 |
| Kast DJ, Dominguez R. (2019) Mechanism of IRSp53 inhibition by 14-3-3. Nature Communications. 10: 483 |
| Kast DJ, Dominguez R. (2017) The Cytoskeleton-Autophagy Connection. Current Biology : Cb. 27: R318-R326 |
| Kast DJ, Dominguez R. (2015) WHAMM links actin assembly via the Arp2/3 complex to autophagy. Autophagy. 11: 1702-4 |
| Kast DJ, Zajac AL, Holzbaur EL, et al. (2015) WHAMM Directs the Arp2/3 Complex to the ER for Autophagosome Biogenesis through an Actin Comet Tail Mechanism. Current Biology : Cb. 25: 1791-7 |
| Kast DJ, Yang C, Disanza A, et al. (2014) Mechanism of IRSp53 inhibition and combinatorial activation by Cdc42 and downstream effectors. Nature Structural & Molecular Biology. 21: 413-22 |
| Boczkowska M, Rebowski G, Kast DJ, et al. (2014) Structural analysis of the transitional state of Arp2/3 complex activation by two actin-bound WCAs. Nature Communications. 5: 3308 |
| Colson BA, Mauseth MA, Kast DJ, et al. (2014) Atomic-Level Visualization of Smooth Muscle Activation by Phosphorylation of the Myosin Regulatory Light Chain Biophysical Journal. 106: 161a-162a |
| Turegun B, Kast DJ, Dominguez R. (2013) Subunit Rtt102 controls the conformation of the Arp7/9 heterodimer and its interactions with nucleotide and the catalytic subunit of SWI/SNF remodelers. The Journal of Biological Chemistry. 288: 35758-68 |
| Disanza A, Bisi S, Winterhoff M, et al. (2013) CDC42 switches IRSp53 from inhibition of actin growth to elongation by clustering of VASP. The Embo Journal. 32: 2735-50 |