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Edward Christopher Hulme

Institution:
Division of Physical Biochemistry
Department:
National Institute for Medical Research
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"Edward Hulme"
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Sukhvinder S. Bansal post-doc 1989 National Institute for Medical Research, Mill Hill, London

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Hulme EC. (2013) GPCR activation: a mutagenic spotlight on crystal structures. Trends in Pharmacological Sciences. 34: 67-84
Kaye RG, Saldanha JW, Lu ZL, et al. (2011) Helix 8 of the M1 muscarinic acetylcholine receptor: scanning mutagenesis delineates a G protein recognition site. Molecular Pharmacology. 79: 701-9
Hulme EC, Trevethick MA. (2010) Ligand binding assays at equilibrium: validation and interpretation. British Journal of Pharmacology. 161: 1219-37
Lebon G, Langmead CJ, Tehan BG, et al. (2009) Mutagenic mapping suggests a novel binding mode for selective agonists of M1 muscarinic acetylcholine receptors. Molecular Pharmacology. 75: 331-41
Goodwin JA, Hulme EC, Langmead CJ, et al. (2007) Roof and floor of the muscarinic binding pocket: variations in the binding modes of orthosteric ligands. Molecular Pharmacology. 72: 1484-96
Bee MS, Hulme EC. (2007) Functional analysis of transmembrane domain 2 of the M1 muscarinic acetylcholine receptor. The Journal of Biological Chemistry. 282: 32471-9
Hulme EC, Bee MS, Goodwin JA. (2007) Phenotypic classification of mutants: a tool for understanding ligand binding and activation of muscarinic acetylcholine receptors. Biochemical Society Transactions. 35: 742-5
Hulme EC, Lu ZL, Saldanha JW, et al. (2003) Structure and activation of muscarinic acetylcholine receptors. Biochemical Society Transactions. 31: 29-34
Hulme EC, Lu ZL, Bee MS. (2003) Scanning mutagenesis studies of the M1 muscarinic acetylcholine receptor. Receptors & Channels. 9: 215-228
Lu ZL, Saldanha JW, Hulme EC. (2002) Seven-transmembrane receptors: crystals clarify. Trends in Pharmacological Sciences. 23: 140-6
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