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Timothy L. Macdonald

Affiliations:

Chemistry

University of Virginia, Charlottesville, VA

Area:

Bioorganic and Synthetic Organic Chemistry

Website:

http://chem.virginia.edu/faculty-research/faculty/timothy-l-macdonald/

Google:

"Timothy L. Macdonald"

Bio:

http://dx.doi.org/10.1021/ar00097a002

Mean distance: 7.02

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Parents

Gilbert Stork	grad student	1975	Columbia
(Part I. Approaches to medium and large carbocycles via thru-carbon ring homologation : a synthesis of [plus or minus]-muscone. Part II. Studies on the transformation of corynanthe alkaloids into yohimbe and rauwolfia alkaloids)
William Summer Johnson	post-doc	1977	Stanford

Children

Jetze J. Tepe	grad student		UVA
William Griffith Humphreys	grad student	1983-1987	UVA
José S. Madalengoitia	grad student	1993	UVA
Lisa Landino	grad student	1989-1994	UVA
Dara Edwards Keller	grad student	2000	UVA
Prakash Ramaseshan Vachaspati	grad student	2000	UVA
Ying Zou	grad student	2000	UVA
Christine Marie Dieckhaus	grad student	2001	UVA
Tiffany Nicole Heady	grad student	2001	UVA
Amy Morin Deveau	grad student	2002	UVA
Michael A. Johnson	grad student	2002	UVA
Webster L. Santos	grad student	2002	UVA
Kirsten S Smith	grad student	1997-2002	UVA
Jayson Michael Rieger	grad student	2003	UVA
Shane G. Roller	grad student	2003	UVA
Jeremy J. Clemens	grad student	2004	UVA
Elizabeth M. Joshi	grad student	2004	UVA
Brian H. Heasley	grad student	2005	UVA
Frank Wells Foss	grad student	2006	UVA
Molly Z. Karlinsey	grad student	2006	UVA
William F. McCalmont	grad student	2006	UVA
Peng Cui	grad student	2007	UVA
Fengping Li	grad student	2008	UVA
Qin Sun	grad student	2008	UVA
Ran Zhu	grad student	2008	UVA
Thomas P. Mathews	grad student	2010	UVA
James E. East	grad student	2011	UVA
Min Yang	grad student	2011	UVA
Andrew J Kennedy	grad student	2007-2011	UVA
Tao Huang	grad student	2012	UVA
Joseph D. Houck	grad student	2013	UVA

Collaborators

Tim McCraw

collaborator

2017-

BETA: Related publications

Publications

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Houck JD, Dawson TK, Kennedy AJ, et al. (2016) Structural Requirements and Docking Analysis of Amidine-Based Sphingosine Kinase 1 Inhibitors Containing Oxadiazoles. Acs Medicinal Chemistry Letters. 7: 487-92
Kennedy AJ, Bruce AM, Gineste C, et al. (2016) Synthesis and Antimicrobial Evaluation of Amixicile-Based Inhibitors of the Pyruvate: Ferredoxin Oxidoreductases of Anaerobic Bacteria and Epsilon Proteobacteria. Antimicrobial Agents and Chemotherapy
East JE, Macdonald TL. (2012) Cost-effective and Large-scale synthesis of 16:0 Lysophosphatidic Acid. Synthetic Communications. 42: 3614-3618
Warren CA, van Opstal E, Ballard TE, et al. (2012) Amixicile, a novel inhibitor of pyruvate: ferredoxin oxidoreductase, shows efficacy against Clostridium difficile in a mouse infection model. Antimicrobial Agents and Chemotherapy. 56: 4103-11
East JE, MacDonald TL. (2012) Cost-effective and large-scale synthesis of 16:0 lysophosphatidic acid Synthetic Communications. 42: 3614-3619
East JE, Carter KM, Kennedy PC, et al. (2011) Development of a phosphatase-resistant, L-tyrosine derived LPA1/LPA3 dual antagonist. Medchemcomm. 2: 325-330
Kharel Y, Mathews TP, Gellett AM, et al. (2011) Sphingosine kinase typeÂ 1 inhibition reveals rapid turnover of circulating sphingosine 1-phosphate. The Biochemical Journal. 440: 345-53
Kennedy PC, Zhu R, Huang T, et al. (2011) Characterization of a sphingosine 1-phosphate receptor antagonist prodrug. The Journal of Pharmacology and Experimental Therapeutics. 338: 879-89
Kennedy AJ, Mathews TP, Kharel Y, et al. (2011) Development of amidine-based sphingosine kinase 1 nanomolar inhibitors and reduction of sphingosine 1-phosphate in human leukemia cells. Journal of Medicinal Chemistry. 54: 3524-48
Ballard TE, Wang X, Olekhnovich I, et al. (2011) Synthesis and antimicrobial evaluation of nitazoxanide-based analogues: identification of selective and broad spectrum activity. Chemmedchem. 6: 362-77